VISDB Viral Integration Site DataBase

VIS ID

TVIS10020297

Fusion event

HBV-NF2 integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1162

End

2258

Orient

+

Integrated sequence

GGTCAGGTCTCTGCCAAGTGTTTGCTGACGCAACCCCCACGGGTTGGGGCTTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAACCGACAACTCAGTTGTCCTCTCTCGGAAATACACCTCCTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGT

Chromosome

chr22

Cytoband

q12.2

Reference genome

Start

End

30062459/29666470 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-let-7a-5p ; hsa-mir-193b-3p ; hsa-mir-1229-3p ; hsa-mir-10a-5p ; hsa-mir-25-3p ; hsa-mir-32-5p ; hsa-mir-92a-3p ; hsa-mir-363-3p ; hsa-mir-367-3p ; hsa-mir-92b-3p ; hsa-mir-185-3p ; hsa-mir-423-5p ; hsa-mir-762 ; hsa-mir-3184-5p ; hsa-mir-4486 ; hsa-mir-4492 ; hsa-mir-4498 ; hsa-mir-4505 ; hsa-mir-5001-5p ; hsa-mir-5787 ; hsa-mir-6085 ; hsa-mir-6813-5p ; hsa-mir-1273e ; hsa-mir-4497 ; hsa-mir-25-5p ; hsa-mir-658 ; hsa-mir-4722-5p ; hsa-mir-1827 ; hsa-mir-6087 ; hsa-mir-219b-3p ; hsa-mir-4459 ; hsa-mir-4768-3p ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-302f ; hsa-mir-4668-5p ; hsa-mir-31-5p ; hsa-mir-5681a ; hsa-mir-6779-5p ; hsa-mir-5589-3p ; hsa-mir-3922-5p ; hsa-mir-4312 ; hsa-mir-4696 ; hsa-mir-454-3p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-301b-3p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-130a-3p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-1273g-3p ; hsa-mir-7703 ; hsa-mir-6729-5p ; hsa-mir-4649-5p ; hsa-mir-1273a ; hsa-mir-661 ; hsa-mir-3117-5p ; hsa-mir-4793-3p ; hsa-mir-766-3p ; hsa-mir-939-3p ; hsa-mir-6849-3p ; hsa-mir-508-5p ; hsa-mir-1228-5p ; hsa-mir-1253 ; hsa-mir-125a-5p ; hsa-mir-125b-5p ; hsa-mir-1285-3p ; hsa-mir-3187-5p ; hsa-mir-326 ; hsa-mir-330-5p ; hsa-mir-345-3p ; hsa-mir-378g ; hsa-mir-4319 ; hsa-mir-4488 ; hsa-mir-4732-3p ; hsa-mir-5189-5p ; hsa-mir-612 ; hsa-mir-670-5p ; hsa-mir-6770-5p ; hsa-mir-6860 ; hsa-mir-7113-3p ; hsa-mir-1207-5p ; hsa-mir-1471 ; hsa-mir-3148 ; hsa-mir-3917 ; hsa-mir-4281 ; hsa-mir-4434 ; hsa-mir-4449 ; hsa-mir-4516 ; hsa-mir-4690-5p ; hsa-mir-4736 ; hsa-mir-4746-5p ; hsa-mir-4763-3p ; hsa-mir-4783-3p ; hsa-mir-4795-5p ; hsa-mir-542-3p ; hsa-mir-5703 ; hsa-mir-6165 ; hsa-mir-6510-5p ; hsa-mir-7150

Nearest miRNA

hsa-mir-1286/Upstream/1205474; hsa-let-7a-3/Downstream/340579;

Nearest TSS

Nearest CpG islands

None/Target, chr22-CpG: 279/Upstream/61258, chr22-CpG: 131/Downstream/53671

Nearest cancer related gene

NF2(TSG, No orient, 0)

Upstream sequence

aacgtccgcctcccagattcaagagattctcctggctcagcctcccaagtagctgggattacaggcatgagacaccatgcccagctaatttttgtatttt

Downstream sequence

aacttttgtatctgcctcctggtgcacataggcaatagtttctttggagtcttgagtatactgggctaggtggggtggctcacgcctgtaatctcagcac

Target sequence

cagtagagacggggtttcaccatattggtaaggctggtctcgaactcctgacctcaggtgacccatccgcctgggcttcccaaagtgctgggattacagtcatgacccactgcgcccagccGATGAGGAATTTTTAAAAAGGAtttttaatgcagtatttcatacatataaaaggataagtgtaacatatgaattataaagaataacaaaagtgaatagctgtgtacccacaaccccactttaagaaatagcaca