Basic Information
VIS ID
TVIS10020317
Fusion event
HBV-chr4 integration
Validated
No
Detection method
VirusScan
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2016
PubMed ID
27339696
Virus Sequence
Virus name
HBV
Reference genome
NC_003977.1
Start
1401
End
2497
Orient
+
Integrated sequence
ATCCTGCGCGGGACGTCCTTTGTCTACGTCCCGTCGGCGCTGAATCCCGCGGACGACCCGTCTCGGGGCCGTTTGGGCCTCTACCGTCCCCTTCTTCATCTGCCGTTCCGGCCGACCACGGGGCGCACCTCTCTTTACGCGGTCTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTAGCATGGAGACCACCGTGAACGCCCACCAGGTCTTGCCCAAGGTCTTACACA
Host Sequence
Chromosome
chr4
Cytoband
q23
Reference genome
GRCh37/hg19
Start
99988074/99066923 (Hg38)
End
99989122/99067971 (Hg38)
Orient
+
Nearest miRNA
hsa-mir-12113/Upstream/69463; hsa-mir-1243/Downstream/2172824;
Nearest TSS
ENST00000502981/Upstream/21733; ENST00000499178/Downstream/154;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/70505, chr4-CpG: 43/Downstream/20614
Nearby gene
METAP1(-3814) ; ADH5(+4055) ;
Upstream sequence
gaccctgacacccattaggctcagcaaattacctgggctgtactgccgcaaggcttcacagacagcccccattacttcagtcaagcccaaatttcatcct
Downstream sequence
ATGAACAGAAATAGTGCTATGTATACTTTTTGGAGCCATTTTTGTTAGGTGTTAAGTTGTACACATGTTGACTGGCTCCACTGTAGTAAAGTTTTGGACA
Target sequence
tggtcttgaactcctggcctcaagtgatcctcccacttcagcctcccacagtgcttggattacaggtgtaagccaccacacccagccAATTTCTACAATTTTTAAATTGATTCTGTGGCTAGGAGAACAAATCACCACACTTCTCTGTGGCAATCTCCTATTTGTGCAGTGATATGACAACTACCAACTGTTTTATTCTATACAGAATGTGACTGGCTATGAAGCAGATTTGCTTTGTTTCAGTAGTTGGGTCAG
Reference
Cao, S., et al.Divergent viral presentation among human tumors and adjacent normal tissues. Sci Rep,2016, 6: 28294.
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