VISDB Viral Integration Site DataBase

VIS ID

TVIS10020325

Fusion event

HBV-WDR72 integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1184

End

2280

Orient

+

Integrated sequence

TGCTGACGCAACCCCCACGGGTTGGGGCTTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAACCGACAACTCAGTTGTCCTCTCTCGGAAATACACCTCCTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTCTACGTCCCGTCGGC

Chromosome

chr15

Cytoband

q21.3

Reference genome

Start

End

53880769/53588572 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-1277-5p ; hsa-mir-297 ; hsa-mir-5590-5p ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-4789-5p ; hsa-mir-3941 ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-567 ; hsa-mir-511-3p ; hsa-mir-5011-5p ; hsa-mir-4789-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-4719 ; hsa-mir-4262 ; hsa-mir-181d-5p ; hsa-mir-181c-5p ; hsa-mir-181b-5p ; hsa-mir-181a-5p

Nearest miRNA

hsa-mir-10393/Upstream/1310324; hsa-mir-11181/Downstream/1784368;

Nearest TSS

Nearest CpG islands

None/Target, chr15-CpG: 55/Upstream/781245, chr15-CpG: 33/Downstream/170886

Upstream sequence

AAGAAATAGCATAATAATACCTCTTGTAAATTAGCATATTTATTATTTCTCCAGAGCTTTTTGGCCTTTATTGATAAAGAATGCCACAACAGTCTTGGCC

Downstream sequence

ACATTCTGATGGGAATGGGATATTCCAAGGGCACTGGGACAAATGGATAATTTTTCCTTCAGCCACCATTTCTCTAGCAATTGCCACATACTAGACACTG

Target sequence

ccatttatttttcctttaAATGTTATATaaatgatgtatgtaggtaggttataatgcttatgaatttcattttaagattttcaagggagcattacaaaatattggctaGGATTGAGAGCACTGAGATCCACTACGATTACTTTTTTTAAAATTTCAAGACTGACCTCATTCTAATGAGAAGAAACATGTGAGGCTGGAAGTTTATATAGACCATGTTCTTAGGCATATTCAGTTACCAAAGAGTGTTTTTACATT