Basic Information
VIS ID
TVIS10020329
Fusion event
HBV-chr8 integration
Validated
No
Detection method
VirusScan
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2016
PubMed ID
27339696
Virus Sequence
Virus name
HBV
Reference genome
NC_003977.1
Start
1141
End
2237
Orient
+
Integrated sequence
TTTACCCCGTTGCCCGGCAACGGTCAGGTCTCTGCCAAGTGTTTGCTGACGCAACCCCCACGGGTTGGGGCTTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAACCGACAACTCAGTTGTCCTCTCTCGGAAATACACCTCCTTTCCATGGCTGCTAGGCTGTGCTGCCA
Host Sequence
Chromosome
chr8
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
55682180/54769620 (Hg38)
End
55683228/54770668 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105375842 ; LOC107984125
Nearest miRNA
hsa-mir-124-1/Upstream/11873345; hsa-mir-10400/Downstream/6944120;
Nearest TSS
ENST00000518652/Upstream/153553; ENST00000522559/Downstream/331721;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/148147, chr8-CpG: 222/Downstream/330428
Upstream sequence
AAGGCAAGGCCACCCTGTTAATAAGCTTAATTGGATTTGCCAGCTGAGCCATGAATTCATTATCCCTGTCAATCCCCAGCCCTAGAGAGCCAAGAAAAAT
Downstream sequence
ATACTATGCTTTTGTAAAGTATCTCAATTTTTTGTTAGTAAAAATCTTATTTGTATTATAAATTACAAAAATCAACTTGTAATTTATATTAACTTCTTTT
Target sequence
AACATTTAGTGTGCAAAATTAATGCAGAATCAACCTTATTTTAAAATTGAGAAAATCAGAAATTAATTTtctctctattttctcctctctctttctttctctctctctctttttcCTCAGATGGCTTCCTTTCATGTCTCAGGGCATAATTCATTCAGAAATTGAACTTTATCTTCAAGGTGAGGATTACTGAAACCATCAGTAGAAGAAAGTACAAGATGATTTTGTTACATCTGGACATCATGGAACACTATT
Reference
Cao, S., et al.Divergent viral presentation among human tumors and adjacent normal tissues. Sci Rep,2016, 6: 28294.
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