Basic Information
VIS ID
TVIS10020339
Fusion event
HBV-RNU6-520P integration
Validated
No
Detection method
VirusScan
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2016
PubMed ID
27339696
Virus Sequence
Virus name
HBV
Reference genome
NC_003977.1
Start
1401
End
2497
Orient
+
Integrated sequence
ATCCTGCGCGGGACGTCCTTTGTCTACGTCCCGTCGGCGCTGAATCCCGCGGACGACCCGTCTCGGGGCCGTTTGGGCCTCTACCGTCCCCTTCTTCATCTGCCGTTCCGGCCGACCACGGGGCGCACCTCTCTTTACGCGGTCTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTAGCATGGAGACCACCGTGAACGCCCACCAGGTCTTGCCCAAGGTCTTACACA
Host Sequence
Chromosome
chr4
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
71567479/70701762 (Hg38)
End
71568527/70702810 (Hg38)
Orient
+
Location type
Intronic
Target gene
RNU6-520P
Nearest miRNA
hsa-mir-12113/Upstream/4424834; hsa-mir-1243/Downstream/5870758;
Nearest TSS
ENST00000502981/Upstream/13283; ENST00000514898/Downstream/1394;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/13006, chr4-CpG: 167/Downstream/1620
Upstream sequence
CCTAAGTGCACTGTACACACTACAAATGTTATCAGAAAGGAGTTATACTTTATGAGTTACTTCACTAGCACAATAAGTAGGTATCGAAAAAAAAATTGAA
Downstream sequence
AGGTATCATGCAGTTAGCAATTCCTAAAAGACAAATATGTCTTCCTGTTGAGATTCTCACCAGCACCAAGAGTTAAGGCCCAAACCACCTTCAAAATGCT
Target sequence
ttcagcagcacatatactaaaattggaatgatacagagattagcatggttcccgtacaaggatgatacacaaatttgtgaagtgttctatatttttACAAAAAACTTTTTAAAAATAGAGGCACAAAAATCCAATACACTGAATGATTTCACAGCATGTCAATGTTTCTATACCTGTAGGTATCTTGACTAACAAGAAAGGAGAAAGCTGGCAATTCAGACTAGATAATGTTTCATATTTTAACTTGGTGACTCC
Reference
Cao, S., et al.Divergent viral presentation among human tumors and adjacent normal tissues. Sci Rep,2016, 6: 28294.
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