VISDB Viral Integration Site DataBase

VIS ID

TVIS10020341

Fusion event

HBV-POLR2H integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1260

End

2356

Orient

+

Integrated sequence

CCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAACCGACAACTCAGTTGTCCTCTCTCGGAAATACACCTCCTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTCTACGTCCCGTCGGCGCTGAATCCCGCGGACGACCCGTCTCGGGGCCGTTTGGGCCTCTACCGTCCCCTTCTTCATCTGCCGTTCCGGCCG

Chromosome

chr3

Cytoband

q27.1

Reference genome

Start

End

184087111/184369323 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-26b-5p ; hsa-let-7b-5p ; hsa-mir-10a-5p

Nearest miRNA

hsa-let-7g/Upstream/126786; hsa-mir-1248/Downstream/883887;

Nearest TSS

Nearest CpG islands

None/Target, chr3-CpG: 148/Upstream/4777, chr3-CpG: 104/Downstream/10582

Upstream sequence

CCTAATGACTAAGAATTGGGGCGATAATGATAGCATTTTTCAAGATGTAATTGAGACAAGAGGGAGAGGTGAGAAATGAGATTATATTTGGGGAAGTCTT

Downstream sequence

ATTCTCTGTGCATTAAACAGTTGTCTGTTTGATCTGGTTTTGCCTGGGAGCTGGTCCCCTGCTGGGATACCTGGGGTATTTCCTTCCCCATCATTTTCGG

Target sequence

GAAGAAGCTAGCCTTCTGAACCTCGCCTGAAGCCAGCCTCTCTGCCAAGTCACTCAGGTCATGGGCATTGTTCAAGCCTGAGTGGCAGCCGCTCTTGCTCACCTGTTGAGGAAGGGCTGGCTCACTGTCCACCGTGGCGGCATCTTTAACTGGCCTCCACTCAATGGGAAACTGACTCGCCTGTGAAAGACACAGTGGGAGAGCTGAAAATGAATCAGAAGCTTTATGTATATGATTTTTAAATTAAACTTTACT