Basic Information
VIS ID
TVIS10020356
Fusion event
HBV-chr2 integration
Validated
No
Detection method
VirusScan
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2016
PubMed ID
27339696
Virus Sequence
Virus name
HBV
Reference genome
NC_003977.1
Start
1
End
915
Orient
+
Integrated sequence
TCCACAACATTCCACCAAGCTCTGCTAGATCCCAGAGTGAGGGGCCTATATTTTCCTGCTGGTGGCTCCAGTTCCGGAACAGTAAACCCTGTTCCGACTACTGCCTCACCCATATCGTCAATCTTCTCGAGGACTGGGGACCCTGCACCGAACATGGAGAGCACAACATCAGGATTCCTAGGACCCCTGCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCACAGAGTCTAGACTCG
Host Sequence
Chromosome
chr2
Cytoband
q35
Reference genome
GRCh37/hg19
Start
216243391/215378668 (Hg38)
End
216244439/215379716 (Hg38)
Orient
+
Location type
Intronic
Target gene
FN1 ; LOC112268430
miRNAs that regulate target gene
hsa-mir-200c-3p ; hsa-mir-200b-3p ; hsa-mir-1-3p ; hsa-let-7g-5p ; hsa-mir-26b-5p ; hsa-mir-615-3p ; hsa-mir-218-5p ; hsa-mir-140-3p
Nearest miRNA
hsa-mir-10b/Upstream/1620509; hsa-mir-1244-1/Downstream/2520797;
Nearest TSS
ENST00000437798/Upstream/2943; ENST00000412951/Downstream/1613;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/66259, chr2-CpG: 43/Downstream/55828
Upstream sequence
TCCTGAACATCGGTCACTTGCATCTGGGATGGTTTGTCAATTTCTACAAATAAAAGCAGGGAGAAACCAGTGAAGCCCCAGTCCTTGGAGACAAGATTGG
Downstream sequence
acggtctctctgtgtcatccaggcggcagtgcagtggagttatcatagctcactgcagccttgaactcgtaggctcaagtgatcctctacctcagcctct
Target sequence
GTTAAGAGGTACATCAGTCCCCTAGGTTCCTAGCAGTTTTCTGCATGTATGTCTGGAAGGATTTTAAAATGTTTTAATGAGGGTAGGCTCAAGGTAGACTGGTACAAACTGTAAAATATTCTTTACCAAGGTAACAGAGCTCAGAAAATGCATAACTAAGTCGATTTATGCATTCAACCAATGGATATGTAAATTGCCCCCCACAACCTTTTAAAATAAGCACAATACATCTAAAAGAGCTGCACAAAATCCAAA
Reference
Cao, S., et al.Divergent viral presentation among human tumors and adjacent normal tissues. Sci Rep,2016, 6: 28294.
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