VISDB Viral Integration Site DataBase

VIS ID

TVIS10020359

Fusion event

HBV-APOE integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1

End

923

Orient

+

Integrated sequence

TCCACAACATTCCACCAAGCTCTGCTAGATCCCAGAGTGAGGGGCCTATATTTTCCTGCTGGTGGCTCCAGTTCCGGAACAGTAAACCCTGTTCCGACTACTGCCTCACCCATATCGTCAATCTTCTCGAGGACTGGGGACCCTGCACCGAACATGGAGAGCACAACATCAGGATTCCTAGGACCCCTGCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCACAGAGTCTAGACTCG

Chromosome

chr19

Cytoband

q13.32

Reference genome

Start

End

45411549/44908292 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-199a-5p ; hsa-mir-1908-5p ; hsa-mir-199a-3p

Nearest miRNA

hsa-mir-10395/Upstream/148523; hsa-let-7e/Downstream/528362;

Nearest TSS

Nearest CpG islands

None/Target, chr19-CpG: 112/Upstream/15509, chr19-CpG: 90/Downstream/171

Upstream sequence

actccagtgggaagtgggggcttttcgaattgctccatcagaagccccagggctcactgtgattcactcatccttgagccaaccactgtgaaccagagga

Downstream sequence

cccaaagtgctgggattagaggcatgagccaccttgcccggccTCCTAGCTCCTtcttcgtctctgcctctgccctctgcatctgctctctgcatctgtc

Target sequence

GATCTTTATTCTCCATCACCCCCACACAGCCCTGCCTGGGGCACACAAGGACACTCAATACATGCTTTTCCgctgggcgcggtggctcacccctgtaatcccagcactttgggaggccaaggtgggaggatcacttgagcccaggagttcaacaccagcctgggcaacatagtgagaccctgtctctactaaaaatacaaaaattagccaggcatggtgccacacacctgtgctctcagctactcaggaggctga