VISDB Viral Integration Site DataBase

VIS ID

TVIS10020361

Fusion event

HBV-KMT2B integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1363

End

2413

Orient

-

Integrated sequence

CCTCCTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTCTACGTCCCGTCGGCGCTGAATCCCGCGGACGACCCGTCTCGGGGCCGTTTGGGCCTCTACCGTCCCCTTCTTCATCTGCCGTTCCGGCCGACCACGGGGCGCACCTCTCTTTACGCGGTCTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTAGCATGGAGACCAC

Chromosome

chr19

Cytoband

q13.12

Reference genome

Start

End

36213129/35722227 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-7515 ; hsa-mir-302a-5p ; hsa-mir-3154 ; hsa-mir-6782-3p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-5692a ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p ; hsa-mir-20b-5p ; hsa-mir-153-3p ; hsa-mir-1224-3p ; hsa-mir-1294 ; hsa-mir-1914-3p ; hsa-mir-214-3p ; hsa-mir-31-5p ; hsa-mir-3184-5p ; hsa-mir-3619-5p ; hsa-mir-3689d ; hsa-mir-423-5p ; hsa-mir-4316 ; hsa-mir-4426 ; hsa-mir-4440 ; hsa-mir-4459 ; hsa-mir-4647 ; hsa-mir-4662b ; hsa-mir-4688 ; hsa-mir-4722-5p ; hsa-mir-5194 ; hsa-mir-6085 ; hsa-mir-6165 ; hsa-mir-6734-5p ; hsa-mir-6738-5p ; hsa-mir-6743-5p ; hsa-mir-6789-5p ; hsa-mir-6813-5p ; hsa-mir-6851-5p ; hsa-mir-761 ; hsa-mir-7704 ; hsa-mir-885-3p

Nearest miRNA

hsa-mir-10395/Upstream/375550; hsa-let-7e/Downstream/3687396;

Nearest TSS

Nearest CpG islands

None/Target, chr19-CpG: 112/Upstream/1153, chr19-CpG: 24/Downstream/1499

Upstream sequence

CTGCGGGAGCGCAAGCTGCCCACACACACTCCGATTTCTCCCCCAGGGTCCCGAGTCCCCTGTGCAAGGTCCCCGCATCAAACATGTCTGCCGTCATGCT

Downstream sequence

ctcctgacctcgtgatctgcccgtctcggcctcccaaagtgctgggattacaggcatcagccaccacacccagcTCCCTGTCCCTATCTTTCCTCACTGT

Target sequence

TGGACCTCACTGACCCGGGAGCTGccccctcctcccccagcccctccacctcccccggccccctccccaccccctgctcctgccacctcctccCGGAGGCCCCTACTCCTTCGGGCCCCTCAGTTTACCCCAAGCGAAGCCCACCTGAAGATCTACGAATCGGTGCTTACTCCTCCTCCTCTTGGGGCTCCTGAAGCCCCTGAGCCAGAGCCTCCTCCTGCCGATGACTCTCCAGCTGAGCCTGAGCCTCGGGCA