Basic Information
VIS ID
TVIS10020366
Fusion event
HBV-chr18 integration
Validated
No
Detection method
VirusScan
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2016
PubMed ID
27339696
Virus Sequence
Virus name
HBV
Reference genome
NC_003977.1
Start
1175
End
2275
Orient
+
Integrated sequence
CCAAGTGTTTGCTGACGCAACCCCCACGGGTTGGGGCTTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAACCGACAACTCAGTTGTCCTCTCTCGGAAATACACCTCCTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTCTACGT
Host Sequence
Chromosome
chr18
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
65969730/68302493 (Hg38)
End
65970780/68303543 (Hg38)
Orient
+
Fragile sites / regions
FRA18C
Nearest miRNA
hsa-mir-1-2/Upstream/1220807; hsa-mir-548av/Downstream/4549778;
Nearest TSS
ENST00000575820/Upstream/37666; ENST00000577835/Downstream/123487;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/785757, chr18-CpG: 67/Downstream/411154
Upstream sequence
tggggtctgaacctagacagtctagctccaaggtcgatgctgttaacaactaGCCAGTTGTTTGTCAAATATAAAGGGGGGCAGAGAGTAAGAGGCATTC
Downstream sequence
ttcaaaaaatcaatgaatccaggagctggttttttgaaaagatcaaaaaaatagaccactagcaagactaataaagaagaaaagagagaagaatcaaata
Target sequence
AAAATGATGTGAAGAACTGAAATAGCTTTATAGTTTTATTAAATATCTTGTGTAGGAAAGTTATTTTAATAGCTCTGTCATTTTTTCCCTTCAATCATGCTAGTAGTAGGAACAGGATTTAATTTAACGTGTATATTCATACCACATAGGGATTAGTAAATGTTTGAATCTTCACAAgtgtcaagaattctacctggtacttcataaattatctctttcagtcagactacagtgctagaaggtatgtactatgat
Reference
Cao, S., et al.Divergent viral presentation among human tumors and adjacent normal tissues. Sci Rep,2016, 6: 28294.
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