VISDB Viral Integration Site DataBase

VIS ID

TVIS10020368

Fusion event

HBV-TMTC2 integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1165

End

2265

Orient

+

Integrated sequence

CAGGTCTCTGCCAAGTGTTTGCTGACGCAACCCCCACGGGTTGGGGCTTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAACCGACAACTCAGTTGTCCTCTCTCGGAAATACACCTCCTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCT

Chromosome

chr12

Cytoband

q21.31

Reference genome

Start

End

83256754/82862975 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-124-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-4470 ; hsa-mir-561-3p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-6734-3p ; hsa-mir-6832-3p ; hsa-mir-6770-5p ; hsa-mir-1253 ; hsa-mir-6761-5p ; hsa-mir-4329 ; hsa-mir-4251

Nearest miRNA

hsa-let-7i/Upstream/1703464; hsa-mir-1178/Downstream/3882093;

Nearest TSS

Nearest CpG islands

None/Target, chr12-CpG: 104/Upstream/174058, chr12-CpG: 17/Downstream/2048446

Upstream sequence

GTTTTCCTGAGGAATTGAGTTTACttttttttttaattaaactttttatttttaGAGAAGTATAAAGTGttaaactaaacgtggcctgaggatgcccctg

Downstream sequence

GTGTGGCTTTCTCTATAGAGAAGAGCATGCGAATAGAGATGCATAGCCTGCAGGTGTTTGCATATTGAATCCACATGTGCTTTTTCCGTTAGTTGCTGGG

Target sequence

ACTTAATATTTACCTTTTTAAAATATGTGGCTGAAATGTTAAAGTGAACTCCTGTACTCTCCCCTTTATACAATGAGAATTTCATTCCTGAGTTAGTGGGGTCTGGAAGGTAGGGTTGGAAGACATGTATGTCAGAAAATAAATTTTCTTGACCTCTCACTAAATGATTGTTTTAGCATTACTTAGATTACTTTCACTCACTTAGTTTTATGTGGTCAAAAAATAAGGGGGGAAAAGCCCTTGAAATACACTTAG