VISDB Viral Integration Site DataBase

VIS ID

TVIS10020375

Fusion event

HBV-TBC1D5 integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1158

End

2258

Orient

+

Integrated sequence

CAACGGTCAGGTCTCTGCCAAGTGTTTGCTGACGCAACCCCCACGGGTTGGGGCTTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAACCGACAACTCAGTTGTCCTCTCTCGGAAATACACCTCCTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGG

Chromosome

chr3

Cytoband

p24.3

Reference genome

Start

End

17217489/17175997 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-375 ; hsa-mir-493-5p ; hsa-mir-4446-5p ; hsa-mir-3679-3p ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-655-5p ; hsa-mir-361-3p ; hsa-mir-329-5p ; hsa-mir-6779-3p

Nearest miRNA

hsa-mir-12127/Upstream/241687; hsa-let-7g/Downstream/2138851;

Nearest TSS

Nearest CpG islands

None/Target, chr3-CpG: 148/Upstream/289597, chr3-CpG: 58/Downstream/566573

Upstream sequence

GGGGGCTATTGCAGTAGTCAAAGTAAGAAGTAAGGAATGGAAATTGGATTGGAGAGTATAACATAAGGAAGGAATATTTTAACCATTATAATAAGTAATA

Downstream sequence

TTTGTGGCTATTGGATCATTAGCTAAAGAGAGTTGGGACTGGAGAACATGgagaggcagcctggtgtgaaaggatgaaaacaggctgtagaatcagacag

Target sequence

GGGCTTTCCTGCTACCACTAGGGCTGATTTTTATCCCCTAAGGAATAAATGTAGGTGAGATATTTCCCAGATGAAGATTTAAGAGATACTAATATGATTAACCGGATCTTAGATTGAGAAGTGGTAGGGGCAGGTGAAGAGAAATTAACATTCATTGATGGTCTATTAAGAGCCAAGTTAATTTTCTTAAAAAGCAAAATGAAGATTGCACAGAAATATAATCAAGGATCCTCTTTGGCATCCAGCTGCCAGAAT