VISDB Viral Integration Site DataBase

VIS ID

TVIS10020376

Fusion event

HBV-MEIS1 integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1119

End

2215

Orient

+

Integrated sequence

CTGTGTAAACAATATCTAAACCTTTACCCCGTTGCCCGGCAACGGTCAGGTCTCTGCCAAGTGTTTGCTGACGCAACCCCCACGGGTTGGGGCTTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAACCGACAACTCAGTTGTCCTCTCTCGGAAATACACCTCCTTTCCA

Chromosome

chr2

Cytoband

p14

Reference genome

Start

End

66725012/66497880 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-204-5p ; hsa-mir-155-5p ; hsa-mir-98-5p ; hsa-let-7a-5p ; hsa-mir-495-3p ; hsa-mir-101-3p ; hsa-mir-21-5p ; hsa-mir-484 ; hsa-mir-196b-5p ; hsa-mir-4311 ; hsa-mir-1286 ; hsa-mir-3667-3p ; hsa-mir-4421 ; hsa-mir-4668-3p ; hsa-mir-4722-5p ; hsa-mir-4780 ; hsa-mir-548c-3p ; hsa-mir-5699-3p ; hsa-mir-623 ; hsa-mir-6511b-5p ; hsa-mir-6748-3p ; hsa-mir-6780b-3p ; hsa-mir-6811-5p ; hsa-mir-6841-3p ; hsa-mir-7152-5p ; hsa-mir-873-5p

Nearest miRNA

hsa-mir-1301/Upstream/138504; hsa-mir-10b/Downstream/2605802;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/50328, chr2-CpG: 129/Downstream/77878

Nearest cancer related gene

MEIS1(OG, No orient, 0)

Upstream sequence

aagacagccatctgcaagccaggaagagggtgctcaccagaaccctaccatgctaacaacctgatctgggacttccagcctctagaactttgagaaatac

Downstream sequence

TGGCTGCCAGCTTAATGTGATGGGACTATTTAGGCAGCACTGCCACCCATTGTTACTCTGAAGCACACTTGCAAAGTTCCAAGTCACTTTACAAGGCTTT

Target sequence

AATGTGGCTATTTTTGACTTTACAAAGCATTGGAACTGGCATCCTCCCATTCTTGTGAACTTTCTCTGGATCTGTAAATACTTGGTATTTGTTTTCTTCCTTGTACATTTCAGGGGTGGTTTTTATATTTAACTTTGACTAAGATACACTCACATGCTACTCTGAGAGTACATGCTTCGGTGTCTCTTTTTTCTTTGCCTTCAGTAAAAAGGATAAGattcagggaaggtttatgaactcactttatgggtcaga