Basic Information
VIS ID
TVIS10020390
Fusion event
HBV-TUBB8P12 integration
Validated
No
Detection method
VirusScan
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2016
PubMed ID
27339696
Virus Sequence
Virus name
HBV
Reference genome
NC_003977.1
Start
1
End
881
Orient
+
Integrated sequence
TCCACAACATTCCACCAAGCTCTGCTAGATCCCAGAGTGAGGGGCCTATATTTTCCTGCTGGTGGCTCCAGTTCCGGAACAGTAAACCCTGTTCCGACTACTGCCTCACCCATATCGTCAATCTTCTCGAGGACTGGGGACCCTGCACCGAACATGGAGAGCACAACATCAGGATTCCTAGGACCCCTGCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCACAGAGTCTAGACTCG
Host Sequence
Chromosome
chr18
Cytoband
p11.32
Reference genome
GRCh37/hg19
Start
63229/63229 (Hg38)
End
64277/64277 (Hg38)
Orient
-
Location type
Intronic
Target gene
TUBB8P12
Nearest miRNA
hsa-mir-1-2/Downstream/47979;
Nearest TSS
ENST00000575820/Upstream/13672; ENST00000580410/Downstream/9240;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/13574, chr18-CpG: 51/Downstream/8785
Upstream sequence
CTTAATGACTAATGGTTAAAATTACTACAAAATACAGTATACAAGAGGGCAGTAATTCGATTTTCATTAAGTTCTACTTCAACCATATGTCTACACTGAT
Downstream sequence
CAACACACTCACATATGCATACCCCTACACATACTGAAATGTCATCTGATTTGTGACCCAAAGAACTCTCAACTAAGAAATAAATGAAAAGTTGCTTACA
Target sequence
tattgtagtcttcacagtctgggcttctttgtgcccattatttttgggaacattttccaggtgttcaaagagacttaggtcccaagcccaaaagcacagtagcaaacatgtagaggtactgctgtggtggccttggattaacattaagaaaaattctcttgatttatcaagtagagattctagttctcttccctttctttctctgaaaccagcagtctctctttctgtgctaagccatgtggagctggagttggg
Reference
Cao, S., et al.Divergent viral presentation among human tumors and adjacent normal tissues. Sci Rep,2016, 6: 28294.
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