VISDB Viral Integration Site DataBase

VIS ID

TVIS10020396

Fusion event

HBV-CNTNAP2 integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1204

End

2300

Orient

+

Integrated sequence

GTTGGGGCTTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAACCGACAACTCAGTTGTCCTCTCTCGGAAATACACCTCCTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTCTACGTCCCGTCGGCGCTGAATCCCGCGGACGACC

Chromosome

chr7

Cytoband

q36.1

Reference genome

Start

End

148009337/148312245 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-218-5p ; hsa-mir-99b-5p ; hsa-mir-4444 ; hsa-mir-6079 ; hsa-mir-4644 ; hsa-mir-4306 ; hsa-mir-185-5p ; hsa-mir-6077 ; hsa-mir-7-5p ; hsa-mir-4428 ; hsa-mir-571 ; hsa-mir-8087 ; hsa-mir-7161-5p ; hsa-mir-548u

Nearest miRNA

hsa-mir-10399/Upstream/933076; hsa-mir-153-2/Downstream/2926176;

Nearest TSS

Nearest CpG islands

None/Target, chr7-CpG: 39/Upstream/2194205, chr7-CpG: 33/Downstream/27157

Nearest cancer related gene

CNTNAP2(TSG, No orient, 0)

Upstream sequence

ctatgagagaaagtctgttctgtgccttgtttctaccttctggtggttttgtggcagtctttggcattccttggctaacctctgccctcataatcacatg

Downstream sequence

cctaggaaggaaaggaattgttgttttgtagaagggattggggtttgggagattagccagacacgatcagcagggaaagcacgtgtgtttttatgataat

Target sequence

ctagaaagtaaatgagttcttcaggagggtaaaagtgagggctgttaaaggaagtctggaggtgtagggagacaggaggtgttgcctagtctgcatgtaaggtggggacaactgtgtaggccctggaagaaagggaaatgcaaagccagtggttgtttgctaaggagggattagaaacggctaggagagaatgagtaaggttgatagcgtggtggagatagctggggagaggtagagggtggcagaggaatggga