Basic Information
VIS ID
TVIS10020404
Fusion event
HBV-LNCPRESS2 integration
Validated
No
Detection method
VirusScan
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2016
PubMed ID
27339696
Virus Sequence
Virus name
HBV
Reference genome
NC_003977.1
Start
1204
End
2300
Orient
+
Integrated sequence
GTTGGGGCTTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAACCGACAACTCAGTTGTCCTCTCTCGGAAATACACCTCCTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTCTACGTCCCGTCGGCGCTGAATCCCGCGGACGACC
Host Sequence
Chromosome
chr4
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
93193835/92272684 (Hg38)
End
93194883/92273732 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA4E
Target gene
LNCPRESS2
Nearest miRNA
hsa-mir-12113/Upstream/4972101; hsa-mir-1243/Downstream/6723655;
Nearest TSS
ENST00000502981/Upstream/384798; ENST00000515744/Downstream/3343;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/89882, chr4-CpG: 63/Downstream/31465
Upstream sequence
GAGCAAATGAGCTGAAAATACAGATCAGTAAATAAAATAAGTTTCAGGATAGAACAAACAATATATTTCACCAGGAAAAATAAAAGATCATGTATGGGAA
Downstream sequence
ttgaggtttgggagattaatcagacacaatcagcagggaaagcacgtgtgtttttatgagaattatgccgagataggtaacagatgaggaagaaatttgg
Target sequence
ggctgagcttattgaggtgtgtctttaaaagatctttagtccgttctacttttcttgaagatggaggaccgtaagggatatgaaggtttcactgaaccctaagagcctgaaaaactaattggctgatttgagtaataaaggctcgtctgttatcagactgtatagaggtgggaaggctaaactgaggaattatgtctgacagaagggaagaaatgactgtggtggccttctcagaccctgtaggaaaggccttta
Reference
Cao, S., et al.Divergent viral presentation among human tumors and adjacent normal tissues. Sci Rep,2016, 6: 28294.
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