VISDB Viral Integration Site DataBase

VIS ID

TVIS10020411

Fusion event

HBV-chr3 integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1204

End

2300

Orient

+

Integrated sequence

GTTGGGGCTTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAACCGACAACTCAGTTGTCCTCTCTCGGAAATACACCTCCTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTCTACGTCCCGTCGGCGCTGAATCCCGCGGACGACC

Chromosome

chr3

Cytoband

p14.3

Reference genome

Start

End

54670751/54636724 (Hg38)

Orient

-

Location type

Intronic

Target gene

CACNA2D3 ; ESRG

miRNAs that regulate target gene

hsa-mir-18a-3p ; hsa-mir-8058 ; hsa-mir-4529-3p ; hsa-mir-5009-5p ; hsa-mir-1269b ; hsa-mir-1269a ; hsa-mir-6516-3p ; hsa-mir-92a-1-5p ; hsa-mir-6503-3p ; hsa-mir-8075 ; hsa-mir-8069 ; hsa-mir-664a-3p ; hsa-mir-758-5p ; hsa-mir-4728-3p ; hsa-mir-6074

Nearest miRNA

hsa-let-7g/Upstream/1789124; hsa-mir-12124/Downstream/1215768;

Nearest TSS

Nearest CpG islands

None/Target, chr3-CpG: 148/Upstream/9065, chr3-CpG: 24/Downstream/833449

Nearest cancer related gene

CACNA2D3(TSG, No orient, 0)

Upstream sequence

AGAAGAAGTGGAAGTCATATCCTTGCTATCTTCTGCTTCTCAGTGTATTTGCTGGTCAGACTTTTGGGCAGCATTTTCTCAGTTAAACTGATTTTTTTTT

Downstream sequence

ggtttgggagattaatcggacacgatcagcagggaaagcacgtgtgtttttatgagaattatgccgagataggtaacagatgaggatgaaatttgggctt

Target sequence

gcttggtgaggtgtgtttttaaaagaccttcagtccattctacctttcttgaagatggaggactgtaagggatataaaggtttcactgaatactaagagcctgaaaaactgcttggctgatttgactaataaagactcatctgttatcagactgtattgaggtgggaaggctaaaatgaggaattatgtctgacagaacggaagaaatgactggtggccttctcagaccctgtaggaaacgcctttacttattca