Basic Information
VIS ID
TVIS10020420
Fusion event
HBV-chr1 integration
Validated
No
Detection method
VirusScan
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2016
PubMed ID
27339696
Virus Sequence
Virus name
HBV
Reference genome
NC_003977.1
Start
1202
End
2298
Orient
+
Integrated sequence
GGGTTGGGGCTTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAACCGACAACTCAGTTGTCCTCTCTCGGAAATACACCTCCTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTCTACGTCCCGTCGGCGCTGAATCCCGCGGACGA
Host Sequence
Chromosome
chr1
Cytoband
q42.2
Reference genome
GRCh37/hg19
Start
231967126/231831380 (Hg38)
End
231968174/231832428 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1H
Target gene
DISC1 ; LOC105373170 ; TSNAX-DISC1
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-6516-5p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-455-3p ; hsa-mir-4451 ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-744-5p ; hsa-mir-4749-5p ; hsa-mir-4706 ; hsa-mir-6499-3p ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-98-5p ; hsa-mir-4500 ; hsa-mir-4458 ; hsa-let-7i-5p ; hsa-let-7g-5p ; hsa-let-7f-5p ; hsa-let-7e-5p ; hsa-let-7d-5p ; hsa-let-7c-5p ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-mir-4537 ; hsa-mir-5186 ; hsa-mir-3192-5p ; hsa-mir-6831-5p ; hsa-mir-3927-3p ; hsa-mir-7851-3p ; hsa-mir-490-3p ; hsa-mir-4291 ; hsa-mir-6895-3p ; hsa-mir-6845-3p ; hsa-mir-136-5p ; hsa-mir-622 ; hsa-mir-545-3p
Nearest miRNA
hsa-mir-101-1/Upstream/811456; hsa-mir-1537/Downstream/1791724;
Nearest TSS
ENST00000473358/Upstream/12475; ENST00000428673/Downstream/327663;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/204011, chr1-CpG: 173/Downstream/796914
Upstream sequence
tctctccttaacacctgactcagttataattttatatgttgtgtgtggcagtggatgttttgtttgcctctctcactagactataaactcagtaaaggca
Downstream sequence
ttgtaagggattgaggtttgggagattagtcagacatgatcagcagggagagcatgtgtgtttttatgagaattatgccgagataggtaacagatgagga
Target sequence
ggactgtgaggctgcaaggagatattttccttggtctaagaaccatttgccttgtgtgggaagagactgataggtggaagtttcagcaggggagtaggtgggaatgactgatgtgaaggagaaaaactggccgtgagggacagaagttggagagctagctgcttgtctagccaccttatcagcataagcgttgcctagagcaatgggatctgacgccttttgatggcctttgcagtgaatgactccagcttcctt
Reference
Cao, S., et al.Divergent viral presentation among human tumors and adjacent normal tissues. Sci Rep,2016, 6: 28294.
Curate