Basic Information
VIS ID
TVIS10020436
Fusion event
HBV-chr2 integration
Validated
No
Detection method
VirusScan
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2016
PubMed ID
27339696
Virus Sequence
Virus name
HBV
Reference genome
NC_003977.1
Start
1175
End
2275
Orient
+
Integrated sequence
CCAAGTGTTTGCTGACGCAACCCCCACGGGTTGGGGCTTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAACCGACAACTCAGTTGTCCTCTCTCGGAAATACACCTCCTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTCTACGT
Host Sequence
Chromosome
chr2
Cytoband
q37.3
Reference genome
GRCh37/hg19
Start
239062523/238153882 (Hg38)
End
239063573/238154932 (Hg38)
Orient
+
Fragile sites / regions
FRA2J
Nearest miRNA
hsa-mir-10b/Upstream/642894; hsa-mir-149/Downstream/913885;
Nearest TSS
ENST00000437798/Upstream/15160; ENST00000486834/Downstream/4050;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/2873, chr2-CpG: 51/Downstream/4004
Nearby gene
KLHL30(-976) ; ERFE(+5126) ;
Upstream sequence
tgctttctcttggactgaccctgacacccatcaagctcagcaaattacctaggctgtactgccacaaagctcacagacagcccccgttacttcaatcaag
Downstream sequence
ACGATTTTGATCACAGTCACATTTAAGAATGTGATTCTTTCCAAAATGGCATTGCATTCAACTGAGAGGAGAGCTAAAGATGATTATTTTAATTAATCTA
Target sequence
ATGCTGGGTAAACTGAGGCCCCTCAGCCTTCAGTGAGCACACAGGGCCCTCAGCCAGGCCCAGCACTGCCAACTGTATCTCAGCTCCCCCGGGTCCCCAAGTAAGCTGGGGCCTAGGCATGCTTCCAGCCACTTCCACCGGACTTGAGTTTTCCAACACCTCACAGACAGGCCCCTTTTATTATCTGGCATCTTCTCTATTCAGGCAGGGACAGTGGTTGCTGGGATCAGGCCATTGACACCCTCATGTGACTGT
Reference
Cao, S., et al.Divergent viral presentation among human tumors and adjacent normal tissues. Sci Rep,2016, 6: 28294.
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