VISDB Viral Integration Site DataBase

VIS ID

TVIS10020442

Fusion event

HBV-KDM4B integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1131

End

2231

Orient

+

Integrated sequence

TATCTAAACCTTTACCCCGTTGCCCGGCAACGGTCAGGTCTCTGCCAAGTGTTTGCTGACGCAACCCCCACGGGTTGGGGCTTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAACCGACAACTCAGTTGTCCTCTCTCGGAAATACACCTCCTTTCCATGGCTGCTAGGC

Chromosome

chr19

Cytoband

p13.3

Reference genome

Start

End

5026734/5026723 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-505-5p ; hsa-mir-106b-3p ; hsa-mir-615-3p ; hsa-mir-491-5p

Nearest miRNA

hsa-mir-1227/Upstream/92933; hsa-let-7e/Downstream/1362915;

Nearest TSS

Nearest CpG islands

None/Target, chr19-CpG: 112/Upstream/39279, chr19-CpG: 48/Downstream/5727

Upstream sequence

agtgctgggattacaggcgtgagccaccgcacctggcTGGGAGTTAGAGGTTTCTAATGCATTGCAGGCAGATAGTGAATACCAGACACGGGGCAGCTGT

Downstream sequence

GGCAGTTTTGTGGTTTTGAAATTGAGTTTGTATCAAGAGCTTTACTGCTTTTGTAAAAACTTACTGGCATGGTACCAAGAGAAATTCAAACAATAGTTGG

Target sequence

ggcctctggggccttagctcttccctggcttcgctgggtccttccctttgcctagactttcctcctgccctggaccgcccAGAACTTGCACCCCTGCGTGTTTGACAATCACTTCCAGACGCAGCCCCGCTGCCACCCAGACCTCTCTGGTCCCAAACCAACTTCATTTGTCTTTTTCCTTTTTTTTAAATTTATTTAtttattttattttacttattaattttttttgagacagagtttcactcgttgcccagg