VISDB Viral Integration Site DataBase

VIS ID

TVIS10020443

Fusion event

HBV-BACE2 integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1150

End

2250

Orient

+

Integrated sequence

TTGCCCGGCAACGGTCAGGTCTCTGCCAAGTGTTTGCTGACGCAACCCCCACGGGTTGGGGCTTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAACCGACAACTCAGTTGTCCTCTCTCGGAAATACACCTCCTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCC

Chromosome

chr21

Cytoband

q22.3

Reference genome

Start

End

42594022/41222095 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-484 ; hsa-mir-2054 ; hsa-mir-1299 ; hsa-mir-3686 ; hsa-mir-4662a-5p ; hsa-mir-5189-3p ; hsa-mir-3607-3p ; hsa-mir-4778-5p ; hsa-mir-3651 ; hsa-mir-1277-5p ; hsa-mir-302c-5p ; hsa-mir-6739-5p ; hsa-mir-3153 ; hsa-mir-6733-5p ; hsa-mir-211-3p ; hsa-mir-7845-5p ; hsa-mir-5584-5p ; hsa-mir-6859-5p ; hsa-mir-3916 ; hsa-mir-3125 ; hsa-mir-583 ; hsa-mir-6868-3p ; hsa-mir-670-5p ; hsa-mir-2277-3p ; hsa-mir-3667-3p ; hsa-mir-6734-3p ; hsa-mir-4319 ; hsa-mir-125b-5p ; hsa-mir-125a-5p ; hsa-mir-4732-3p ; hsa-mir-345-3p ; hsa-mir-1207-3p ; hsa-mir-141-5p ; hsa-mir-4526 ; hsa-mir-3660 ; hsa-mir-498 ; hsa-mir-4279 ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-1303 ; hsa-mir-5096 ; hsa-mir-3149 ; hsa-mir-3912-5p ; hsa-mir-197-3p ; hsa-mir-411-5p ; hsa-mir-6755-3p ; hsa-mir-198 ; hsa-mir-6832-5p ; hsa-mir-193b-5p ; hsa-mir-4716-5p ; hsa-mir-4673 ; hsa-mir-4645-5p ; hsa-mir-483-5p ; hsa-mir-6848-3p ; hsa-mir-6843-3p ; hsa-mir-378a-5p ; hsa-mir-6131 ; hsa-mir-3663-5p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-874-3p ; hsa-mir-3157-3p ; hsa-mir-4448 ; hsa-mir-6861-3p ; hsa-mir-6821-3p ; hsa-mir-3182 ; hsa-mir-149-5p ; hsa-mir-4794 ; hsa-mir-664a-5p ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-1248 ; hsa-mir-1237-3p ; hsa-mir-4723-3p ; hsa-mir-6769b-3p ; hsa-mir-3183 ; hsa-mir-6800-3p ; hsa-mir-3064-5p ; hsa-mir-6504-5p ; hsa-mir-1226-5p ; hsa-mir-25-5p ; hsa-mir-3616-3p ; hsa-mir-433-5p ; hsa-mir-4487 ; hsa-mir-4710 ; hsa-mir-4721 ; hsa-mir-4730 ; hsa-mir-553 ; hsa-mir-7160-3p

Nearest miRNA

hsa-let-7c/Upstream/53416; hsa-mir-5692b/Downstream/524677;

Nearest TSS

Nearest CpG islands

None/Target, chr21-CpG: 261/Upstream/52100, chr21-CpG: 16/Downstream/23795

Upstream sequence

gcactttgggaggctgaggcgggtggatcacttgaagtcaggagttcaagaccagcctgggcaacacagtgagaccccatctcaaaaaaaaagtatatta

Downstream sequence

gttgagcaagtcagactctctgcacctcagtgtttgcatctgtgacgtggagtgaggactgtgctgccctcagagctctgttatgaggttgaaataagct

Target sequence

aaaaaaaAAAAAAAAAACAGTAGAGTGCCTTTGCCATTGTTTTAGATTCACTTCAAACCTTCATCCCCCAAATCTGTTTCCCTACCATTCCTACAAAGTTTTTGTGAACATGATCTTCATTGGTCGGGAGGGAATTCTCTGAAGTCACAAAGTAGCTTTTCGTTTGAGAAAACACAGGGGTGTGACCACAGGTTACAGCACTGCCCCTGGCAGATGCCCAGGACTGTCGTTCATTCCTCTCCACTATTTCCATGG