VISDB Viral Integration Site DataBase

VIS ID

TVIS10020444

Fusion event

HBV-HACE1 integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1108

End

2208

Orient

+

Integrated sequence

ACAAGGCCTTTCTGTGTAAACAATATCTAAACCTTTACCCCGTTGCCCGGCAACGGTCAGGTCTCTGCCAAGTGTTTGCTGACGCAACCCCCACGGGTTGGGGCTTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAACCGACAACTCAGTTGTCCTCTCTCGGAAATACA

Chromosome

chr6

Cytoband

q16.3

Reference genome

Start

End

105165710/104717835 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-193b-3p ; hsa-mir-190a-3p ; hsa-mir-3924 ; hsa-mir-5011-5p ; hsa-mir-223-5p ; hsa-mir-6887-5p ; hsa-mir-7111-5p ; hsa-mir-6795-5p ; hsa-mir-6870-5p ; hsa-mir-5698 ; hsa-mir-4723-5p ; hsa-mir-3175 ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-8085 ; hsa-mir-149-3p ; hsa-mir-6731-5p ; hsa-mir-766-5p ; hsa-mir-4644 ; hsa-mir-4306 ; hsa-mir-185-5p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-4756-5p ; hsa-mir-4739 ; hsa-mir-1321 ; hsa-mir-6758-5p ; hsa-mir-6856-5p ; hsa-mir-552-5p ; hsa-mir-1179 ; hsa-mir-892c-3p ; hsa-mir-4676-3p ; hsa-mir-452-5p ; hsa-mir-7703 ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-196a-3p ; hsa-mir-661 ; hsa-mir-4252 ; hsa-mir-4424 ; hsa-mir-6860 ; hsa-mir-612 ; hsa-mir-5189-5p ; hsa-mir-3187-5p ; hsa-mir-1285-3p ; hsa-mir-4793-3p ; hsa-mir-766-3p ; hsa-mir-939-3p ; hsa-mir-6849-3p ; hsa-mir-1273g-3p ; hsa-mir-508-5p ; hsa-mir-4797-5p ; hsa-mir-6083 ; hsa-mir-297 ; hsa-mir-567 ; hsa-mir-511-3p ; hsa-mir-1273e ; hsa-mir-3614-5p ; hsa-mir-3689d ; hsa-mir-377-5p ; hsa-mir-4459 ; hsa-mir-4537 ; hsa-mir-455-3p ; hsa-mir-5694 ; hsa-mir-6086 ; hsa-mir-6134 ; hsa-mir-6499-3p ; hsa-mir-6500-3p ; hsa-mir-6516-5p ; hsa-mir-665 ; hsa-mir-6840-3p ; hsa-mir-6851-5p ; hsa-mir-6880-5p ; hsa-mir-7847-3p

Nearest miRNA

hsa-mir-10398/Upstream/5592089; hsa-mir-1202/Downstream/2066290;

Nearest TSS

Nearest CpG islands

None/Target, chr6-CpG: 120/Upstream/3313687, chr6-CpG: 79/Downstream/141409

Nearest cancer related gene

HACE1(TSG, No orient, 0)

Upstream sequence

tgccttgatattcatcactattccctttaatctttggagccccctttgaggtagacatgactaggagctccatttcataaatgagaagatggtgaagctg

Downstream sequence

gcatagccatatcctttgtccatttgcctatcgagtttcctgtctttcttatcactatgcaagatttgtttatatattctgtatgttaacccctcattgg

Target sequence

ttgccacaaagcacttcatagaatgaagcacaaatggccagtaaattataaaaatgctgcttaactttttaataattgggaaaatgaaaattaaaatatacagcgataccagttgacaccaactgtattggcaagattttgtaaatctgacagtctcaagtgctggcaagaatctagaaaaaccacatctcttagacactgctagagagtatcacccctttggaaaacaattgtgatcatctattaaagttggag