VISDB Viral Integration Site DataBase

VIS ID

TVIS10020466

Fusion event

HBV-CCNE1 integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1808

End

2904

Orient

+

Integrated sequence

GCACCATGCAACTTTTTCCCCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGCTTCTGTGGAGTTACTCTCTTTTTTGCCTTCTGACTTCTTTCCTTCTATTCGAGATCTCCTCGACACCGCCTCTGCTCTGTATCGGGAGGCCTTAGAGTCTCCGGAACATTGTTCACCTCACCATACAGCAC

Chromosome

chr19

Cytoband

q12

Reference genome

Start

End

30304354/29813447 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-15b-5p ; hsa-mir-503-5p ; hsa-mir-424-5p ; hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-107 ; hsa-mir-185-5p ; hsa-mir-103a-3p ; hsa-mir-26b-5p ; hsa-mir-26a-5p ; hsa-mir-16-1-3p ; hsa-mir-195-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-151a-3p ; hsa-mir-342-5p ; hsa-mir-125b-5p ; hsa-mir-92a-3p ; hsa-mir-383-3p ; hsa-mir-497-5p ; hsa-mir-4524a-5p ; hsa-mir-4694-3p ; hsa-mir-4524b-5p ; hsa-mir-6838-5p ; hsa-mir-7-5p ; hsa-mir-4477a ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-5191 ; hsa-mir-646 ; hsa-mir-25-5p ; hsa-mir-30c-2-3p ; hsa-mir-144-5p ; hsa-mir-892b

Nearest miRNA

hsa-mir-10395/Upstream/9413045; hsa-let-7e/Downstream/5309253;

Nearest TSS

Nearest CpG islands

chr19-CpG: 137/Target, None/Upstream, None/Downstream

Nearest cancer related gene

CCNE1(OG, No orient, 0)

Upstream sequence

gtccaaccccacaggagggcaggctccttccagcccagcccccagggcccaccctggtctagcctcgatcctgccgcctcctctgcgctccctgccatcc

Downstream sequence

GGGTGTTTATAAGCAACAACTTTCCCCCTATCTACACCTATTTTTCTTGTCATGGTGTTTAAGGACCTCCTCCGTCTTCTGTAGGTCAGATTTCAAATTC

Target sequence

gggTCGCGGGTGACAGGCCACCCCGCCATCGGCCATCTTCCTGGCTCGCCCGGCCGCCCGCGCGCAAAGGGGGAAGGGGTACTGGGCCCGCGGCCTGACCCCGCCGCCGCCTCACCCCGCGCCGCCCCGCAGGCCTCAGGCCGGAGCAGCCCCATCATGCCGAGGGAGCGCAGGGAGCGGTGAGTGCCCGCGCCGcggggccggacgggacgggacgggacgggacgggTGGCGTGGGGGAGGGGCGGCCGCGGG