VISDB Viral Integration Site DataBase

VIS ID

TVIS10020469

Fusion event

HBV-MTRF1L integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1179

End

2275

Orient

+

Integrated sequence

GTGTTTGCTGACGCAACCCCCACGGGTTGGGGCTTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAACCGACAACTCAGTTGTCCTCTCTCGGAAATACACCTCCTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTCTACGTCCCG

Chromosome

chr6

Cytoband

q25.2

Reference genome

Start

End

153312468/152991333 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-125b-5p ; hsa-mir-196a-5p ; hsa-mir-26a-5p ; hsa-mir-17-5p ; hsa-mir-222-5p ; hsa-mir-6802-5p ; hsa-mir-4536-5p ; hsa-mir-223-3p ; hsa-mir-4697-3p ; hsa-mir-876-3p ; hsa-mir-323a-5p ; hsa-mir-4451 ; hsa-mir-379-5p ; hsa-mir-3529-5p ; hsa-mir-4650-3p ; hsa-mir-6815-3p ; hsa-mir-103a-2-5p ; hsa-mir-4722-5p ; hsa-mir-1286 ; hsa-mir-873-5p ; hsa-mir-423-5p ; hsa-mir-3184-5p ; hsa-mir-1205 ; hsa-mir-3129-5p ; hsa-mir-199b-3p ; hsa-mir-199a-3p ; hsa-mir-936 ; hsa-mir-6865-5p ; hsa-mir-6815-5p ; hsa-mir-6813-5p ; hsa-mir-6085 ; hsa-mir-6743-5p ; hsa-mir-4688 ; hsa-mir-6873-5p ; hsa-mir-509-5p ; hsa-mir-509-3-5p ; hsa-mir-4418 ; hsa-mir-7850-5p ; hsa-mir-7152-5p ; hsa-mir-3074-5p ; hsa-mir-3180-5p ; hsa-mir-6839-3p ; hsa-mir-6783-3p ; hsa-mir-1343-3p ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-629-5p ; hsa-mir-3140-3p ; hsa-mir-6829-3p ; hsa-mir-6791-3p ; hsa-mir-1976 ; hsa-mir-766-3p ; hsa-mir-342-3p ; hsa-mir-6742-3p ; hsa-mir-6852-5p ; hsa-mir-939-3p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-660-3p ; hsa-mir-4267 ; hsa-mir-6849-3p ; hsa-mir-216b-3p ; hsa-mir-208b-5p ; hsa-mir-208a-5p ; hsa-mir-508-5p

Nearest miRNA

hsa-mir-10398/Upstream/1887509; hsa-mir-1202/Downstream/1862027;

Nearest TSS

Nearest CpG islands

None/Target, chr6-CpG: 120/Upstream/6447, chr6-CpG: 63/Downstream/11066

Upstream sequence

gaaattctggagctgaacaatataagtggcatactgaagaatgcatcagagttctttaatagcagaatgggtcaagcagaaaaaaagaattaatgagctt

Downstream sequence

ACGAGAATTAAAAAGTTTTAATAAAAAAATCTTCTTTACTTATTATCAAGGAATACTTTTCCTCCTCATCCTTTTTCTTCTTCCTTTATGAGGGGAAAAA

Target sequence

attaatatctgaatcctgcctcagccacttcaatgttctatgacctcgggcaacttagtttcccgatctgcaaaatacagtgtctactacacagtgatgatgacaatagagcctggcacatagATGCTATTCCTATAGTCGCTGAATACATATAATCTCTGTGAATTAATGCAGTCATCTTCCGTGGTAACAAGGTGGTGAGTTTCCCATATTGAGGAATTCTTAAAAGGCTCTGTAGTTATAAAATTAAATACC