VISDB Viral Integration Site DataBase

VIS ID

TVIS10020474

Fusion event

HBV-OSTF1 integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1183

End

2279

Orient

+

Integrated sequence

TTGCTGACGCAACCCCCACGGGTTGGGGCTTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAACCGACAACTCAGTTGTCCTCTCTCGGAAATACACCTCCTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTCTACGTCCCGTCGG

Chromosome

chr9

Cytoband

q21.13

Reference genome

Start

End

77709115/75094199 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-429 ; hsa-mir-1-3p ; hsa-mir-26b-5p ; hsa-mir-4735-5p ; hsa-mir-4668-3p ; hsa-mir-548c-3p ; hsa-mir-6844 ; hsa-mir-378a-5p ; hsa-mir-6821-3p ; hsa-mir-6749-3p ; hsa-mir-6790-3p ; hsa-mir-3653-5p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-7108-3p ; hsa-mir-4258 ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-6848-3p ; hsa-mir-6843-3p ; hsa-mir-3187-3p ; hsa-mir-4435 ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-548s ; hsa-mir-6131 ; hsa-mir-4755-3p ; hsa-mir-3663-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-1273f ; hsa-mir-1289 ; hsa-mir-129-5p ; hsa-mir-136-5p ; hsa-mir-143-3p ; hsa-mir-3120-5p ; hsa-mir-3198 ; hsa-mir-325 ; hsa-mir-3685 ; hsa-mir-384 ; hsa-mir-411-5p ; hsa-mir-4294 ; hsa-mir-4309 ; hsa-mir-4317 ; hsa-mir-4534 ; hsa-mir-4708-5p ; hsa-mir-4770 ; hsa-mir-5571-3p ; hsa-mir-6088 ; hsa-mir-6514-5p ; hsa-mir-6832-5p ; hsa-mir-6888-3p ; hsa-mir-7975 ; hsa-mir-8055 ; hsa-mir-8082

Nearest miRNA

hsa-mir-101-2/Upstream/4283067; hsa-let-7a-1/Downstream/8875549;

Nearest TSS

Nearest CpG islands

None/Target, chr9-CpG: 64/Upstream/4248, chr9-CpG: 148/Downstream/796115

Upstream sequence

gtgcagtggcgcaatcttggctcaccataacctccacctcccgggttcaagtgattctcctgcctcagactcctgagtagctgggattacaggtgcctgc

Downstream sequence

ATTATTGGTATTTGGTTTGTGTAACTGCCCTCTTTCAATGGATCCGTATTAGAGCATTAAACTATGCACTTTTTGAGAGTGGAACAGTCTTTTATTTCTT

Target sequence

cttccagagtatctggaattatagatgctcaccaccaaacctggcTGAGACCCTCCTTTCCTTTTTCTGAATGAGTACAACCTCTTAGTTTTACACATATAGCATTTATGTTGTTTTCAGCCACTCTCAGAAGCCTTGCAGTTCAATTAGCGTGAATCTGTCTGGCTTGTTAGAGTGTAGAAGTGTAGAAAACAGAACTTTTGTTCTTGTAAAATCTTTTTAAAAATATTTTATTCTGAGAGTAAGAATGGGCCA