VISDB Viral Integration Site DataBase

VIS ID

TVIS10020480

Fusion event

HBV-AFG1L integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1142

End

2238

Orient

+

Integrated sequence

TTACCCCGTTGCCCGGCAACGGTCAGGTCTCTGCCAAGTGTTTGCTGACGCAACCCCCACGGGTTGGGGCTTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAACCGACAACTCAGTTGTCCTCTCTCGGAAATACACCTCCTTTCCATGGCTGCTAGGCTGTGCTGCCAA

Chromosome

chr6

Cytoband

q21

Reference genome

Start

End

108776455/108455252 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-let-7b-5p ; hsa-mir-1228-5p ; hsa-mir-6770-3p ; hsa-mir-4730 ; hsa-mir-6787-5p ; hsa-mir-663a ; hsa-mir-1908-5p ; hsa-mir-4467 ; hsa-mir-6809-5p ; hsa-mir-571 ; hsa-mir-4715-5p ; hsa-mir-3141

Nearest miRNA

hsa-mir-10398/Upstream/1669984; hsa-mir-1202/Downstream/10613795;

Nearest TSS

Nearest CpG islands

None/Target, chr6-CpG: 120/Upstream/159010, chr6-CpG: 477/Downstream/102375

Upstream sequence

ctggaagaatggtagatctacttttagatctttgagaagtcttcacactttttccatagaggttgtactaattcacatttcctaccaacaatgtataagc

Downstream sequence

aaacaagattgaccatgccatgtattgagtgggtgattttacattggggttttaatagaactattctcttcacatgtgtttatgtgtaaaatttttcata

Target sequence

AGTTtgcatggtgtcacaatggaatagtgatggtatcagtggaaaaataccacacagtttaagactataaaatttatttagcagtcaaggttgcagaaatgtatccacatggagacacttgcacaaaacagaagataatagagcatattcccagatgaagctgtaagtttttttggcctttgagggcccattaggtgacaaagatagcacctgatcaagataaggatcccattagatcacctttgtcattcttag