VISDB Viral Integration Site DataBase

VIS ID

TVIS10020485

Fusion event

HBV-RNF216 integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1469

End

2565

Orient

+

Integrated sequence

CCGTTTGGGCCTCTACCGTCCCCTTCTTCATCTGCCGTTCCGGCCGACCACGGGGCGCACCTCTCTTTACGCGGTCTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTAGCATGGAGACCACCGTGAACGCCCACCAGGTCTTGCCCAAGGTCTTACACAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTT

Chromosome

chr7

Cytoband

p22.1

Reference genome

Start

End

5787837/5748206 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-455-3p ; hsa-mir-320a ; hsa-mir-376a-3p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-5089-5p ; hsa-mir-4279 ; hsa-mir-1200 ; hsa-mir-4465 ; hsa-mir-26b-5p ; hsa-mir-26a-5p ; hsa-mir-1297 ; hsa-mir-1911-5p ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-544b ; hsa-mir-4324 ; hsa-mir-660-3p ; hsa-mir-6513-3p ; hsa-mir-8062 ; hsa-mir-7851-3p ; hsa-mir-619-3p ; hsa-mir-5698 ; hsa-mir-744-3p ; hsa-mir-1178-3p ; hsa-mir-891a-3p ; hsa-mir-143-5p ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3140-3p ; hsa-mir-3135b ; hsa-mir-3934-3p ; hsa-mir-6499-3p ; hsa-mir-5693 ; hsa-mir-484 ; hsa-mir-3155b ; hsa-mir-3155a ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-93-5p ; hsa-mir-17-5p ; hsa-mir-4662a-3p

Nearest miRNA

hsa-mir-339/Upstream/35248; hsa-mir-10399/Downstream/1318758;

Nearest TSS

Nearest CpG islands

None/Target, chr7-CpG: 39/Upstream/138805, chr7-CpG: 91/Downstream/32807

Upstream sequence

TCCTAATCTTAAAGTGAAACTGTTTTTTTCAAGTTGTAAGTGCTTGAAGCTATTTAAGTGCTTACTACATTTTTCTGCCTCCTTTCAACTAAAGTGTTAC

Downstream sequence

agtttctgccagcttatagaggctgcacacaaactgtctttgtgccctacagttcaccttttgaaggaaaaagccaaattccacctcattttaatgctga

Target sequence

AGAACAACCTGAAAATGTAGCATGAAATTCCTGACTTACATGCTACGGATAAAAACAGGTCATAGTTTAAAAATGTCCTAAACCTGGGGAAGACTTTCAGACATTTTTTAAAGAATTCAGAGTCTTAATTATAACTTATGATCCTAGGATACCTGACTTATTACCAGCTAACACATGGTGGGACCAGGGGAAGGAGAGGGAGTAAAAACGGATAAAAGCAGCAGAAGCAGAATATTATTTTCCTGAGGATGATAT