VISDB Viral Integration Site DataBase

VIS ID

TVIS10020490

Fusion event

HBV-MAFF integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1752

End

2800

Orient

-

Integrated sequence

TTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCCCCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGCTTCTGTGGAGTTACTCTCTTTTTTGCCTTCTGACTTCTTTCCTTCTATTCGAGATCTCCTCGACACCGCCTCTGC

Chromosome

chr22

Cytoband

q13.1

Reference genome

Start

End

38602761/38206754 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-5698 ; hsa-mir-6885-3p ; hsa-mir-744-3p ; hsa-mir-4423-5p ; hsa-mir-6501-5p ; hsa-mir-143-5p ; hsa-mir-675-5p ; hsa-mir-4466 ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-31-3p ; hsa-mir-6499-3p ; hsa-mir-4781-3p

Nearest miRNA

hsa-mir-1286/Upstream/216853; hsa-let-7a-3/Downstream/2607129;

Nearest TSS

Nearest CpG islands

None/Target, chr22-CpG: 279/Upstream/2725, chr22-CpG: 67/Downstream/7574

Upstream sequence

CCTCCAGAAGACGTCATGAACCTGCAGACCCTGGAGGTCAGCTCTGCTGGCTTCCAAGGGAAGAAGCCAGGGAGAGGTGGTGGTGGCCGACATAGAAGAC

Downstream sequence

GTGCCTCTGAGGTTCTGTATCAGCCGCAACACCCAAAGGGCAGTTGATTAACTTGCGTGGGGAGAGGCTTCCCTTCTCCCATTGGGTCTTTCTGTGTAGC

Target sequence

AGAGGACCCCTGGGTTCCAGTCCGCCACGGCTACCAAACAGTGGCTTGGTTGCCTCAGGTGCTGAACAGGGGATCGGATCAGCTACTATTTCTCAGGCCCAGGGTCAGCCAGCCTGGCAAAGGCAGAGGACCCAGGCCCCTTGGCAGCCCCTGGCCTGGGGTTGGCAGCGGAAAGCCTGAGGTTACCAGAAAGTTCCCCCTTCTTGTGACTTTCCCCCTGTGATTGCCTGACTGCTGAGCTAGGACATTCCTGGG