VISDB Viral Integration Site DataBase

VIS ID

TVIS10020508

Fusion event

HBV-CHL1 integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1185

End

2281

Orient

+

Integrated sequence

GCTGACGCAACCCCCACGGGTTGGGGCTTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAACCGACAACTCAGTTGTCCTCTCTCGGAAATACACCTCCTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTCTACGTCCCGTCGGCG

Chromosome

chr3

Cytoband

p26.3

Reference genome

Start

End

441148/399465 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-10a-5p ; hsa-mir-335-5p ; hsa-mir-132-3p ; hsa-mir-181a-5p ; hsa-mir-590-5p ; hsa-mir-182-5p

Nearest miRNA

hsa-let-7g/Downstream/4850712;

Nearest TSS

Nearest CpG islands

None/Target, chr3-CpG: 148/Upstream/89207, chr3-CpG: 182/Downstream/1698880

Nearest cancer related gene

CHL1(OG, No orient, 0)

Upstream sequence

AGAGGACTGGAAAAGGTTAACCGGCTTCAGCTCTACACTGCTGACTTAGACTGACAGCAATTGCGTTCCTTCTCTTGCTCTCTGGTTCTCTCAAACAGTG

Downstream sequence

cccgtctctactaaaaatacaaaaattagccgggcatggtggcagctgcctgtaatcccagctactcggaaggctgagacaggagaatcacttgaacccg

Target sequence

AGTCAATCTATGTCCTGTAGAATACTTAGTGTTGCCTGTGTCCTATATTAAACATAAAAACACTGAGTGTATTAATTATGAAAATCGTAATTTCAATTTGTTTTGACATATTTTTAAATTATCAAAATGAAAAATGTTTCACAGTAGTCCACCATCCTTTATTTTGTTTTTACTAGAGTTGTTGCCTAAAAATATCTCCTGCTAATTAACATATCTTAATAACACAAACTAAAAAGAAAAAGCAAAACAAAACAA