Basic Information
VIS ID
TVIS10020524
Fusion event
HBV-chr5 integration
Validated
No
Detection method
VirusScan
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2016
PubMed ID
27339696
Virus Sequence
Virus name
HBV
Reference genome
NC_003977.1
Start
1178
End
2274
Orient
+
Integrated sequence
AGTGTTTGCTGACGCAACCCCCACGGGTTGGGGCTTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAACCGACAACTCAGTTGTCCTCTCTCGGAAATACACCTCCTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTCTACGTCCC
Host Sequence
Chromosome
chr5
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
107853182/108517481 (Hg38)
End
107854230/108518529 (Hg38)
Orient
+
Fragile sites / regions
FRA5F
Nearest miRNA
hsa-mir-10397/Upstream/7700916; hsa-mir-103a-1/Downstream/1995300;
Nearest TSS
ENST00000502646/Upstream/135383; ENST00000513676/Downstream/209731;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/134881, chr5-CpG: 34/Downstream/209505
Upstream sequence
gccggatgaaagcaattttaactagtgcaagatggtatcttagagtagttttcacttctaattctctgattatccatgatgttgagaaccttttttcatt
Downstream sequence
tcacgtagacctgcactgcctcacccctacataccctctatgccaaaactttcccttcataaacccttgcatttcacctggaaacttgaagcggttccat
Target sequence
TTTCTTTACCTCTTAGATTGTTTTGATTTTAAGAAGTAGATAACATGTAGCAAGAAACTTCTACTTTTATGGTTAGTTTGTGTGGTGGAACAAGTTTTTAGACAAGGAAGTCATCAGGATACTTTTTAAAAACAAATAAATTGCATATGAATGTTTTCAACAGATATTTTCTGAAGATCTCGTATTCCTCGGTATCCAGACTATCTGGGTGCCAGAGATCACCAGAAACCTAACATGGTCTCGTCTTCAGGCCTG
Reference
Cao, S., et al.Divergent viral presentation among human tumors and adjacent normal tissues. Sci Rep,2016, 6: 28294.
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