VISDB Viral Integration Site DataBase

VIS ID

TVIS10020536

Fusion event

HBV-RYR3 integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1142

End

2238

Orient

+

Integrated sequence

TTACCCCGTTGCCCGGCAACGGTCAGGTCTCTGCCAAGTGTTTGCTGACGCAACCCCCACGGGTTGGGGCTTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAACCGACAACTCAGTTGTCCTCTCTCGGAAATACACCTCCTTTCCATGGCTGCTAGGCTGTGCTGCCAA

Chromosome

chr15

Cytoband

q13.3

Reference genome

Start

End

33668874/33376673 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-124-3p ; hsa-mir-26b-5p ; hsa-mir-367-5p

Nearest miRNA

hsa-mir-1268a/Upstream/2310484; hsa-mir-10393/Downstream/1005396;

Nearest TSS

Nearest CpG islands

None/Target, chr15-CpG: 55/Upstream/63823, chr15-CpG: 114/Downstream/661695

Upstream sequence

agtttgagaccagcctggccaacatagtgaaacccttctctactaaaaatacaaaaattagtgggggtgtgctggcgggcactgtaatctcagctacttg

Downstream sequence

tagtactccacaacatccacttcaTCTGTctaaggtcacgttttcctctgtgttctcttctagaagttttatggtccgaactttcacatccatgtctgtg

Target sequence

ATCAGAGCAAGCCCAGATTCAAGGCAAACATTAtttcttattgaagtataatttttacacagtaaaatgcacagatctcaaatctacaatttgctgaattttgacaattgcatacatctgtgtaaccaccaatgaaattaagatatagaacatttctggccaggcgcagtggctcatgcctgtaatcccagcactctgggaggccgaggcgggcggatcatgaggtcaggagattgagaccatcctggctaacac