Basic Information
VIS ID
TVIS10020539
Fusion event
HBV-chr21 integration
Validated
No
Detection method
VirusScan
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2016
PubMed ID
27339696
Virus Sequence
Virus name
HBV
Reference genome
NC_003977.1
Start
1161
End
2257
Orient
+
Integrated sequence
CGGTCAGGTCTCTGCCAAGTGTTTGCTGACGCAACCCCCACGGGTTGGGGCTTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAACCGACAACTCAGTTGTCCTCTCTCGGAAATACACCTCCTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACG
Host Sequence
Chromosome
chr21
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
14683593/13311272 (Hg38)
End
14684641/13312320 (Hg38)
Orient
+
Nearest miRNA
hsa-mir-10396a/Upstream/4323607; hsa-let-7c/Downstream/94064;
Nearest TSS
ENST00000624081/Upstream/6120; ENST00000427446/Downstream/233713;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/2683548, chr21-CpG: 39/Downstream/297295
Upstream sequence
caggactcctgcctgctccacggagcgaggctgggtatgcagccctggtttgggcagctgcagcagcacccggggagctaccaccccaactcagaagggg
Downstream sequence
ggcgtgagccaccacacctggccACATATATAGTTCTAAacacacacacagagacacacacagacacacacacacacacacagagacacgcagacacaca
Target sequence
tggggctccagcttgtccacagtcccctggctccacacagtaggcagccccaaccgcgcctccctgctccagccgggtgatggcAGTGGCAGGTTGTCTGGAGGGCTGCTACCATCACGGGAACCAAATGAAAGTAAAAGTAAGCCACAGTGCTTAGAACGGTTTCAGACAGGACAGAAGCCAAATTACAAAAAGATGGAGGCATAAGGTCAAAGATAGACTGTCATATCTTGATTTAACTAATTATTGTATGAA
Reference
Cao, S., et al.Divergent viral presentation among human tumors and adjacent normal tissues. Sci Rep,2016, 6: 28294.
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