Basic Information
VIS ID
TVIS10020540
Fusion event
HBV-NOCT integration
Validated
No
Detection method
VirusScan
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2016
PubMed ID
27339696
Virus Sequence
Virus name
HBV
Reference genome
NC_003977.1
Start
1179
End
2275
Orient
+
Integrated sequence
GTGTTTGCTGACGCAACCCCCACGGGTTGGGGCTTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAACCGACAACTCAGTTGTCCTCTCTCGGAAATACACCTCCTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTCTACGTCCCG
Host Sequence
Chromosome
chr4
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
139948929/139027775 (Hg38)
End
139949977/139028823 (Hg38)
Orient
+
Location type
Intronic
Target gene
NOCT
miRNAs that regulate target gene
hsa-mir-296-3p ; hsa-let-7e-5p
Nearest miRNA
hsa-mir-12113/Upstream/13520468; hsa-mir-1305/Downstream/4314637;
Nearest TSS
ENST00000502981/Upstream/11979; ENST00000515616/Downstream/14249;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/11501, chr4-CpG: 18/Downstream/54091
Upstream sequence
GGTTAACACAGTATCTACCATTTCTAATTTTGTTATCATTTTTCTTTATCATCTTGATGGTAAAACAGAAGATTTGTTTCTTTGTGTAAATAATGTTAAT
Downstream sequence
ATAGCCTTCTCTttttgttttgttttgttttgttttgagactgagtcttgctctgtcgcccaggctggagtgcagtggcgtgatctcggctcactgcaac
Target sequence
gcttgagccaacgcgcctggcctatttatgaacattaaaatttgaatttcatatcattttcacatgtcatgaaatattactgttcttaaggttccccccctccccctaccatttaaaaatataaaagcctttcttagcttgcaggcagcacaaagacaggatgctgccagagttagctcatgggtcacagtcggtagatccctgATCTAGAGAGGACTCTGTACAGTCAGCAGAAGGCGCCTTATAGTTTCATAT
Reference
Cao, S., et al.Divergent viral presentation among human tumors and adjacent normal tissues. Sci Rep,2016, 6: 28294.
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