VISDB Viral Integration Site DataBase

VIS ID

TVIS10020554

Fusion event

HBV-AFF3 integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1268

End

2364

Orient

+

Integrated sequence

TACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAACCGACAACTCAGTTGTCCTCTCTCGGAAATACACCTCCTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTCTACGTCCCGTCGGCGCTGAATCCCGCGGACGACCCGTCTCGGGGCCGTTTGGGCCTCTACCGTCCCCTTCTTCATCTGCCGTTCCGGCCGACCACGGG

Chromosome

chr2

Cytoband

q11.2

Reference genome

Start

End

100416126/99799664 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

FRA2S ; FRA2A

Target gene

miRNAs that regulate target gene

hsa-mir-574-5p ; hsa-mir-6881-3p ; hsa-mir-6780a-3p ; hsa-mir-7111-3p ; hsa-mir-6867-5p ; hsa-mir-3177-5p ; hsa-mir-7703 ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-1227-3p ; hsa-mir-4252 ; hsa-mir-4793-3p ; hsa-mir-766-3p ; hsa-mir-1273g-3p ; hsa-mir-508-5p ; hsa-mir-6849-3p

Nearest miRNA

hsa-mir-1285-2/Upstream/3000263; hsa-mir-10b/Downstream/1509786;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/204587, chr2-CpG: 138/Downstream/304259

Nearest cancer related gene

AFF3(OG, No orient, 0)

Upstream sequence

CCGTGCTGTTTCCCAAGGGGCTGGGCCTCCTTCGGGACATCTATGCTTACCTGGAGGCTGGTGGGTTATAGCGAGGTGGGGGCACGGGTCCCCCCAAAGC

Downstream sequence

aacttgaaaaacaagaataaaatcgaaagattatactatttgatagaaaatcatacagctatagtgaccaagacagtgtgataccagtgtaaggactgac

Target sequence

atatatattacatgctaacattaatcaaaagaaagctgaattggctatattaatattaaggtagatcttaacgcagccagggataaagaagtttatatcacattgtctaacggaccaatcaatatgacgtaaaaatctaaatgcttatgtgcctaacagcagagcttcaaaatacacgaagcaaaagtgaatacaacttcaaggagaaatagacagtcccttaattatagtcagagatttcagtatcctgcccta