VISDB Viral Integration Site DataBase

VIS ID

TVIS10020556

Fusion event

HBV-SPATS2L integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1268

End

2364

Orient

+

Integrated sequence

TACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAACCGACAACTCAGTTGTCCTCTCTCGGAAATACACCTCCTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTCTACGTCCCGTCGGCGCTGAATCCCGCGGACGACCCGTCTCGGGGCCGTTTGGGCCTCTACCGTCCCCTTCTTCATCTGCCGTTCCGGCCGACCACGGG

Chromosome

chr2

Cytoband

q33.1

Reference genome

Start

End

201236198/200371475 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-21-5p ; hsa-mir-146a-5p ; hsa-mir-103a-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-6873-3p ; hsa-mir-433-3p ; hsa-mir-7154-5p ; hsa-mir-942-5p ; hsa-mir-6845-3p ; hsa-mir-4762-5p ; hsa-mir-548av-3p ; hsa-mir-548f-3p ; hsa-mir-548e-3p ; hsa-mir-548az-3p ; hsa-mir-548ar-3p ; hsa-mir-548a-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-1273e ; hsa-mir-25-3p ; hsa-mir-25-5p ; hsa-mir-32-5p ; hsa-mir-363-3p ; hsa-mir-367-3p ; hsa-mir-377-5p ; hsa-mir-4325 ; hsa-mir-4459 ; hsa-mir-4537 ; hsa-mir-455-3p ; hsa-mir-4695-5p ; hsa-mir-6086 ; hsa-mir-6087 ; hsa-mir-6499-3p ; hsa-mir-6516-5p ; hsa-mir-658 ; hsa-mir-665 ; hsa-mir-6840-3p ; hsa-mir-7703 ; hsa-mir-92a-3p ; hsa-mir-92b-3p

Nearest miRNA

hsa-mir-10b/Upstream/11237316; hsa-mir-1244-1/Downstream/6411759;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/62658, chr2-CpG: 44/Downstream/154487

Upstream sequence

CAGGAACTTATGAAGCGGGCGGGTGACTGTGGTGACTTCACATGGGCCAAGAAACTCAGGGGTTCATTGCTGCAGGTGGGCTTTCAGGAAGGGGAGATTG

Downstream sequence

gatgcatggatccccattgtagaatatgtttgagcaaggtctggatggctatttaatgaggatattgACTGCGGGATTAACTTACAGCTCAGGAGTATGT

Target sequence

agtttcaatggattcacaactaggtttgcataacaaacccagagagtgccaaagaatgggtcagtgtaattgcggagggtaaccagtatagactctgttctattccagatctctctttatcagtgacatgaatgGTGATGATTTTGATGAAACAATAGAaataactgacatttattgaactcttatgtgtcaaaaactgttctattattctatatatattagtttatttaatcttcacaattctgtgtagttgat