VISDB Viral Integration Site DataBase

VIS ID

TVIS10020557

Fusion event

HBV-ESR1 integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1285

End

2381

Orient

+

Integrated sequence

CAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAACCGACAACTCAGTTGTCCTCTCTCGGAAATACACCTCCTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTCTACGTCCCGTCGGCGCTGAATCCCGCGGACGACCCGTCTCGGGGCCGTTTGGGCCTCTACCGTCCCCTTCTTCATCTGCCGTTCCGGCCGACCACGGGGCGCACCTCTCTTTACG

Chromosome

chr6

Cytoband

q25.1

Reference genome

Start

End

152064453/151743318 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-302c-3p ; hsa-mir-206 ; hsa-mir-193b-3p ; hsa-mir-18b-5p ; hsa-mir-18a-5p ; hsa-mir-22-3p ; hsa-mir-19a-3p ; hsa-mir-29b-3p ; hsa-mir-19b-3p ; hsa-mir-20b-5p ; hsa-mir-221-3p ; hsa-mir-222-3p ; hsa-mir-130a-3p ; hsa-mir-26a-5p ; hsa-mir-145-5p ; hsa-mir-3668 ; hsa-mir-4671-3p ; hsa-mir-4709-3p ; hsa-mir-7852-3p ; hsa-mir-100-5p ; hsa-mir-142-3p ; hsa-mir-6073 ; hsa-mir-6757-3p ; hsa-mir-4422 ; hsa-mir-548e-5p ; hsa-mir-454-3p ; hsa-mir-130b-3p ; hsa-mir-301a-3p ; hsa-mir-301b-3p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-129-5p ; hsa-mir-874-3p ; hsa-mir-3157-3p ; hsa-mir-4290 ; hsa-mir-5582-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-5589-3p ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-7855-5p ; hsa-mir-9-5p ; hsa-mir-4264 ; hsa-mir-4797-3p ; hsa-mir-3121-5p ; hsa-mir-1910-5p ; hsa-mir-26b-3p ; hsa-mir-192-5p ; hsa-mir-335-3p

Nearest miRNA

hsa-mir-10398/Upstream/639494; hsa-mir-1202/Downstream/3110042;

Nearest TSS

Nearest CpG islands

None/Target, chr6-CpG: 120/Upstream/247878, chr6-CpG: 105/Downstream/64369

Nearest cancer related gene

ESR1(TSG, No orient, 0)

Upstream sequence

TACAAAGTTAAAAATCAAAAACTCTTTCCCTATTTATTAGCTTCTGTTTCTATCTCAGATGCTAAAAGAAGTAGTGTGGTGTTTTTATGAAAAGAAAATA

Downstream sequence

TGCCCATGAGCTCCTTCCGTCTCCTGATGTGCCTCAGCAATTTCATGTGCAAAGTACACAAGAGCCATTTGTTGGAAAGTACCTAAATCACTCTATTTAC

Target sequence

tcagaagagggttttctggatcacagagtaattctattcttaattttttgagaaaatttcatactgttttccgtaatggctgcagcaatctacactgccaccaacagggtacagggttcccttttctccacacgctcaccaacacttgctatttcttgtctttttggtaatagAAGGGCAGGGCATCATTAATATTGTTTCCCTTACATGTGCTGAACAAACacagcagagcagttaccagcgctaactctggaa