VISDB Viral Integration Site DataBase

VIS ID

TVIS10020561

Fusion event

HBV-chr3 integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1185

End

2281

Orient

+

Integrated sequence

GCTGACGCAACCCCCACGGGTTGGGGCTTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAACCGACAACTCAGTTGTCCTCTCTCGGAAATACACCTCCTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTCTACGTCCCGTCGGCG

Chromosome

chr3

Cytoband

p14.3

Reference genome

Start

End

54652238/54618211 (Hg38)

Orient

+

Location type

Intronic

Target gene

CACNA2D3 ; LOC107986088

miRNAs that regulate target gene

hsa-mir-18a-3p ; hsa-mir-8058 ; hsa-mir-4529-3p ; hsa-mir-5009-5p ; hsa-mir-1269b ; hsa-mir-1269a ; hsa-mir-6516-3p ; hsa-mir-92a-1-5p ; hsa-mir-6503-3p ; hsa-mir-8075 ; hsa-mir-8069 ; hsa-mir-664a-3p ; hsa-mir-758-5p ; hsa-mir-4728-3p ; hsa-mir-6074

Nearest miRNA

hsa-let-7g/Upstream/1770611; hsa-mir-12124/Downstream/1234281;

Nearest TSS

Nearest CpG islands

None/Target, chr3-CpG: 148/Upstream/494165, chr3-CpG: 33/Downstream/7951

Nearest cancer related gene

CACNA2D3(TSG, No orient, 0)

Upstream sequence

tgagattagtgttatcaattctgtctgatagtgaaagaattcaactcagagagtccaggttctgttcagtggagatgcatataatgaacagctgagctgg

Downstream sequence

ATAATTATCTTACTACACATATGCACTACAATGTGAGTACAAAGATGTTTACTATAGTAATGTTGAAAACATAAAATACTGAAAATTTAAACTTTCACTA

Target sequence

AAGTGCATGTGTTTTGGCACACCTTTGCTACCCTGGCCTGCATCAGTGTGTTTTTCTAGAATATGGACCTTGCTACTGCCACTAAAAGGCTGTACCTCTTCTGAGAAGCTGCTTGTAAGTCGACTGTTCTTATCTGTCCAGCACCTCTCTCTCTCATCCTTTACATGAAATCCCTCTGTCCTTAGAAAACCCATTTGGTGAAGTCAGGTAGGACTTTCCCCATTTCTccccaccacaccctcaagttcagacgtg