VISDB Viral Integration Site DataBase

VIS ID

TVIS10020579

Fusion event

HBV-FAM160B1 integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1101

End

2197

Orient

+

Integrated sequence

CCAACTTACAAGGCCTTTCTGTGTAAACAATATCTAAACCTTTACCCCGTTGCCCGGCAACGGTCAGGTCTCTGCCAAGTGTTTGCTGACGCAACCCCCACGGGTTGGGGCTTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAACCGACAACTCAGTTGTCCTCTCTCGG

Chromosome

chr10

Cytoband

q25.3

Reference genome

Start

End

116650425/114890666 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

FRA10D ; FRA10A ; FRA10B

Target gene

miRNAs that regulate target gene

hsa-mir-421 ; hsa-mir-151a-5p ; hsa-let-7e-5p ; hsa-mir-5011-5p ; hsa-mir-942-3p ; hsa-mir-4789-5p ; hsa-mir-133a-3p ; hsa-mir-133b ; hsa-mir-3148 ; hsa-mir-545-5p ; hsa-mir-3185 ; hsa-mir-3688-3p ; hsa-mir-3978 ; hsa-mir-4694-3p ; hsa-mir-505-3p ; hsa-mir-570-5p ; hsa-mir-548ag ; hsa-mir-548ai ; hsa-mir-548ba ; hsa-mir-5094 ; hsa-mir-3074-3p ; hsa-mir-512-3p ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-522-3p ; hsa-mir-224-3p ; hsa-mir-20b-5p ; hsa-mir-526b-3p ; hsa-mir-93-5p ; hsa-mir-106a-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-519d-3p ; hsa-mir-106b-5p ; hsa-mir-1207-3p ; hsa-mir-582-3p ; hsa-mir-548f-3p ; hsa-mir-548e-3p ; hsa-mir-548az-3p ; hsa-mir-548ar-3p ; hsa-mir-548a-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-455-5p ; hsa-mir-3133 ; hsa-mir-3941 ; hsa-mir-5580-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-8485 ; hsa-mir-329-3p

Nearest miRNA

hsa-mir-107/Upstream/715439; hsa-mir-202/Downstream/1936822;

Nearest TSS

Nearest CpG islands

None/Target, chr10-CpG: 68/Upstream/66943, chr10-CpG: 39/Downstream/47468

Upstream sequence

ggtgccctctttcatctatgtatttctaacatttagaacatTATACCTTATAGAAAATTCCTTAGCAAATTAATTAAGTGAATAATTGGAAGAAAAATTT

Downstream sequence

atataccgtatatgacatatagtatataaaatatataccgtatatgacatatatagtatataaaatatatactgtatatgacatacatatagtatataaa

Target sequence

ctccatcatccctatccacattaacaagcccaactcagaccatcttctcaatggctgaccctgacctgcagtggagcaccaccactgaatggattagcagtgctgatgccccctcaccagcacattccagtgccctggctgaagggcgtgtcctttgggccctccaagggttgctcctctggtggatcttctagcttgacatgaaatagccatccaagcatcctactcgccttagcctctgtcccttagcgttcc