Basic Information
VIS ID
TVIS10020580
Fusion event
HBV-chr16 integration
Validated
No
Detection method
VirusScan
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2016
PubMed ID
27339696
Virus Sequence
Virus name
HBV
Reference genome
NC_003977.1
Start
1
End
1049
Orient
-
Integrated sequence
TCCACAACATTCCACCAAGCTCTGCTAGATCCCAGAGTGAGGGGCCTATATTTTCCTGCTGGTGGCTCCAGTTCCGGAACAGTAAACCCTGTTCCGACTACTGCCTCACCCATATCGTCAATCTTCTCGAGGACTGGGGACCCTGCACCGAACATGGAGAGCACAACATCAGGATTCCTAGGACCCCTGCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCACAGAGTCTAGACTCG
Host Sequence
Chromosome
chr16
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
72094262/72060363 (Hg38)
End
72095310/72061411 (Hg38)
Orient
+
Location type
Intronic
Target gene
HP ; TXNL4B
miRNAs that regulate target gene
hsa-mir-574-5p ; hsa-mir-6803-5p ; hsa-mir-6751-5p ; hsa-mir-6867-5p ; hsa-mir-4472 ; hsa-mir-4447 ; hsa-mir-3650 ; hsa-mir-4455 ; hsa-mir-6747-5p ; hsa-mir-7110-5p ; hsa-mir-6842-5p ; hsa-mir-6752-5p ; hsa-mir-6835-5p ; hsa-mir-8064 ; hsa-mir-4643 ; hsa-mir-8485 ; hsa-mir-3622b-5p ; hsa-mir-3689d ; hsa-mir-4327 ; hsa-mir-4459 ; hsa-mir-4537 ; hsa-mir-455-3p ; hsa-mir-4633-3p ; hsa-mir-5197-5p ; hsa-mir-6134 ; hsa-mir-6499-3p ; hsa-mir-6500-5p ; hsa-mir-6516-5p ; hsa-mir-665 ; hsa-mir-6840-3p ; hsa-mir-6851-5p ; hsa-mir-6874-5p ; hsa-mir-6880-5p
Nearest miRNA
hsa-mir-1225/Upstream/2029941; hsa-mir-11401/Downstream/4807525;
Nearest TSS
ENST00000527434/Upstream/4202; ENST00000566168/Downstream/1813;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/51374, chr16-CpG: 15/Downstream/31819
Upstream sequence
TAAGTTCCCTACACTATGAAACAGTCTTAGTGTGGAGATTGCAAATGCCTTGCCTCTAGGCTGAAGACGGCCCTAGGTGTGGGTACTCTTAAAAAAAATA
Downstream sequence
cctcAAAGTGAATTAGGAGAAAAGGCATGGGCCTGGTTGAGGAAGAGGCTAGCTCAAAATGGGATGGGGAAAAAGTGTTTTAACACAGACAGTACTTCAG
Target sequence
AGATTGAGAAGGTTGTTCTACACCCTAACTACTCCCAGGTAGATATTGGGCTCATCAAACTCAAACAGAAGGTGTCTGTTAATGAGAGAGTGATGCCCATCTGCCTACCTTCAAAGGATTATGCAGAAGTAGGGCGTGTGGGTTATGTTTCTGGCTGGGGGCGAAATGCCAATTTTAAATTTACTGACCATCTGAAGTATGTCATGCTGCCTGTGGCTGACCAAGACCAATGCATAAGGCATTATGAAGGCAGCA
Reference
Cao, S., et al.Divergent viral presentation among human tumors and adjacent normal tissues. Sci Rep,2016, 6: 28294.
Curate