Basic Information
VIS ID
TVIS10020599
Fusion event
HBV-chr17 integration
Validated
No
Detection method
VirusScan
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2016
PubMed ID
27339696
Virus Sequence
Virus name
HBV
Reference genome
NC_003977.1
Start
104
End
1200
Orient
+
Integrated sequence
CCTCACCCATATCGTCAATCTTCTCGAGGACTGGGGACCCTGCACCGAACATGGAGAGCACAACATCAGGATTCCTAGGACCCCTGCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCACAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAGCACCCACGTGTCCTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTT
Host Sequence
Chromosome
chr17
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
80278693/82320817 (Hg38)
End
80279741/82321865 (Hg38)
Orient
+
Location type
Intronic
Target gene
CD7 ; SECTM1
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-7977 ; hsa-mir-6778-3p ; hsa-mir-1281 ; hsa-mir-615-3p ; hsa-mir-6746-3p ; hsa-mir-6499-5p ; hsa-mir-6752-3p ; hsa-mir-181d-3p
Nearest miRNA
hsa-mir-10226/Upstream/84089; hsa-mir-4525/Downstream/346368;
Nearest TSS
ENST00000595228/Upstream/3215; ENST00000333437/Downstream/6641;
Nearest CpG islands
chr17-CpG: 26/Target, None/Upstream, None/Downstream
Upstream sequence
TTAGCTCTGCGTCGGATCCCTGAGAACTTCGAAGCCATCCTGGCTGAGGCTAATCTCCGCTGTGCTTCCTCTGCAGTATGAAGACTTTGGAGACTCAACC
Downstream sequence
AGGGAGTCCGGGTCTGTGGGTTTGATGAGGGCAGAGGGAGGGGCATGCGTCCTGGTAAGTCGGGTGCTGCGGAGGTGAGGTGGTTCCATTTTGGAAACTG
Target sequence
caaaacaaaggcaaaaaactgaatagattaaaagtgtgtgttggggccctcccctcctccagcacggggcctaggctgctgtttgagtgagttccactgagcttcccggggccagttgattcctgtcttggacaaaacgttccagaaagtcaaaagagtgggatgtgtccagcccactttataaggctaggatgacagcaactccaaaccaacaagaacagacaaaagcagaacatgagaggcccgtttcactcc
Reference
Cao, S., et al.Divergent viral presentation among human tumors and adjacent normal tissues. Sci Rep,2016, 6: 28294.
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