VISDB Viral Integration Site DataBase

VIS ID

TVIS10020604

Fusion event

HBV-ARHGAP18 integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1

End

904

Orient

+

Integrated sequence

TCCACAACATTCCACCAAGCTCTGCTAGATCCCAGAGTGAGGGGCCTATATTTTCCTGCTGGTGGCTCCAGTTCCGGAACAGTAAACCCTGTTCCGACTACTGCCTCACCCATATCGTCAATCTTCTCGAGGACTGGGGACCCTGCACCGAACATGGAGAGCACAACATCAGGATTCCTAGGACCCCTGCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCACAGAGTCTAGACTCG

Chromosome

chr6

Cytoband

q22.33

Reference genome

Start

End

129963544/129642399 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-6818-3p ; hsa-mir-593-3p ; hsa-mir-6895-3p ; hsa-mir-4725-5p ; hsa-mir-4696 ; hsa-mir-570-3p ; hsa-mir-5699-3p ; hsa-mir-520f-5p ; hsa-mir-4421 ; hsa-mir-6501-3p ; hsa-mir-339-5p ; hsa-mir-451b ; hsa-mir-10b-5p ; hsa-mir-3667-5p ; hsa-mir-10a-5p ; hsa-mir-4282 ; hsa-mir-6759-5p ; hsa-mir-6796-5p ; hsa-mir-4322 ; hsa-mir-4296 ; hsa-mir-4265 ; hsa-mir-4439 ; hsa-mir-3136-5p ; hsa-mir-4769-5p ; hsa-mir-4654 ; hsa-mir-6778-5p ; hsa-mir-1233-5p ; hsa-mir-4648 ; hsa-mir-3118 ; hsa-mir-134-5p ; hsa-mir-5196-5p ; hsa-mir-4747-5p ; hsa-mir-6857-3p ; hsa-mir-6855-3p ; hsa-mir-4513 ; hsa-mir-15b-3p ; hsa-mir-581 ; hsa-mir-5187-3p ; hsa-mir-2681-3p ; hsa-mir-6848-5p ; hsa-mir-6846-5p ; hsa-mir-4697-5p ; hsa-mir-4488 ; hsa-mir-1237-5p ; hsa-mir-486-3p

Nearest miRNA

hsa-mir-10398/Upstream/3156638; hsa-mir-1202/Downstream/2149773;

Nearest TSS

Nearest CpG islands

None/Target, chr6-CpG: 120/Upstream/711177, chr6-CpG: 208/Downstream/376642

Upstream sequence

AATATCAATGTTTCCCTTCTTCACTGTTAATGTAAATGACTCACAATTTTTTTTAACCTATAACAGTATAGGTAAGTTAAGTCTCTTATTTCTTATATGA

Downstream sequence

tcagtctcctgaggagctactactacaggtatataccatattgcccagctaatttttttttttttggcagacatggggtcttgctgtgttgcccaggttg

Target sequence

agagtcaaagttagaggacagcagattataaatcaataaaacaaagatcaaaagaactcaagctgactgaccactggaaaaacagtctcactgcaaagcagtgctctatcaccatctgcactcactagagaccaaatgacaatgtggctaccacatcacagaagaaatttaaagggaggttagatggtttcaaagatgaagtctaactctaaaaagctatgatACAGTGAGCTTAGCCAACAACATTCCAGCCAT