VISDB Viral Integration Site DataBase

VIS ID

TVIS10020610

Fusion event

HBV-CCND1 integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1170

End

2266

Orient

+

Integrated sequence

CTCTGCCAAGTGTTTGCTGACGCAACCCCCACGGGTTGGGGCTTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAACCGACAACTCAGTTGTCCTCTCTCGGAAATACACCTCCTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTC

Chromosome

chr11

Cytoband

q13.3

Reference genome

Start

End

69467526/69652758 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

FRA11H ; FRA11A

Target gene

miRNAs that regulate target gene

hsa-mir-20a-5p ; hsa-mir-195-5p ; hsa-mir-193b-3p ; hsa-mir-424-5p ; hsa-mir-16-1-3p ; hsa-mir-34a-5p ; hsa-mir-503-5p ; hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-let-7b-5p ; hsa-mir-19a-3p ; hsa-mir-302a-3p ; hsa-mir-15b-5p ; hsa-mir-449a ; hsa-mir-17-5p ; hsa-mir-302c-3p ; hsa-mir-106b-5p ; hsa-let-7e-5p ; hsa-mir-365a-3p ; hsa-mir-19b-1-5p ; hsa-mir-520b ; hsa-mir-34b-3p ; hsa-mir-338-3p ; hsa-mir-9-5p ; hsa-mir-374b-5p ; hsa-mir-425-5p ; hsa-mir-155-5p ; hsa-mir-1-3p ; hsa-mir-183-5p ; hsa-mir-93-5p ; hsa-mir-26b-5p ; hsa-let-7f-5p ; hsa-mir-196a-5p ; hsa-mir-92a-3p ; hsa-mir-138-5p ; hsa-mir-106a-5p ; hsa-mir-27a-3p ; hsa-mir-383-5p ; hsa-mir-490-3p ; hsa-mir-603 ; hsa-mir-142-5p ; hsa-mir-340-5p ; hsa-mir-448 ; hsa-mir-548k ; hsa-mir-3609 ; hsa-mir-548ah-5p ; hsa-mir-3973 ; hsa-mir-5590-3p ; hsa-mir-548av-5p ; hsa-mir-8054 ; hsa-mir-6077 ; hsa-mir-214-5p ; hsa-mir-558 ; hsa-mir-1234-3p ; hsa-mir-4524a-5p ; hsa-mir-4694-3p ; hsa-mir-4524b-5p ; hsa-mir-1199-3p ; hsa-mir-6735-3p ; hsa-mir-6748-3p ; hsa-mir-6874-5p ; hsa-mir-7107-5p ; hsa-mir-497-5p ; hsa-mir-545-3p ; hsa-mir-4311 ; hsa-mir-4672 ; hsa-mir-6838-5p ; hsa-mir-8066 ; hsa-mir-3157-5p ; hsa-mir-4691-3p ; hsa-mir-758-5p ; hsa-mir-374a-5p ; hsa-mir-4708-5p ; hsa-mir-4756-3p ; hsa-mir-193a-3p ; hsa-mir-4691-5p ; hsa-mir-6792-3p ; hsa-mir-655-5p ; hsa-mir-4709-3p ; hsa-mir-20b-5p ; hsa-mir-520a-3p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-491-3p ; hsa-mir-216b-3p ; hsa-mir-6500-3p ; hsa-mir-593-3p ; hsa-mir-204-3p ; hsa-mir-494-3p ; hsa-mir-4261 ; hsa-mir-4646-5p ; hsa-mir-4666a-5p ; hsa-mir-4781-3p ; hsa-mir-708-5p ; hsa-mir-29a-3p ; hsa-mir-24-3p ; hsa-mir-152-3p ; hsa-mir-206 ; hsa-mir-3907 ; hsa-mir-5196-5p ; hsa-mir-4747-5p ; hsa-mir-5589-5p ; hsa-mir-4731-5p ; hsa-mir-7706 ; hsa-mir-5706 ; hsa-mir-4782-5p ; hsa-mir-516b-5p ; hsa-mir-1299 ; hsa-mir-563 ; hsa-mir-380-5p ; hsa-mir-1193 ; hsa-mir-8069 ; hsa-mir-4537 ; hsa-mir-202-3p ; hsa-mir-2392 ; hsa-let-7c-5p ; hsa-let-7g-5p ; hsa-let-7a-5p ; hsa-let-7d-5p ; hsa-mir-4500 ; hsa-mir-98-5p ; hsa-let-7i-5p ; hsa-mir-4458 ; hsa-mir-6848-3p ; hsa-mir-6843-3p ; hsa-mir-3191-5p ; hsa-mir-513a-5p ; hsa-mir-7112-3p ; hsa-mir-6875-5p ; hsa-mir-3126-5p ; hsa-mir-1253 ; hsa-mir-3663-5p ; hsa-mir-6824-3p ; hsa-mir-6764-3p ; hsa-mir-330-5p ; hsa-mir-326 ; hsa-mir-7845-5p ; hsa-mir-518c-5p ; hsa-mir-9500 ; hsa-mir-6873-5p ; hsa-mir-5197-3p ; hsa-mir-95-3p ; hsa-mir-6500-5p ; hsa-mir-4633-3p ; hsa-mir-574-5p ; hsa-mir-5010-3p ; hsa-mir-147a ; hsa-mir-6818-5p ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-5087 ; hsa-mir-298 ; hsa-mir-4748 ; hsa-mir-4464 ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-3714 ; hsa-mir-548an ; hsa-mir-96-5p ; hsa-mir-1271-5p ; hsa-mir-593-5p ; hsa-mir-145-3p ; hsa-mir-676-5p ; hsa-mir-5009-3p ; hsa-mir-4715-5p ; hsa-mir-541-5p ; hsa-mir-3591-3p ; hsa-mir-21-3p ; hsa-mir-556-5p ; hsa-mir-4796-3p ; hsa-mir-891b ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-369-3p ; hsa-mir-944 ; hsa-mir-1257 ; hsa-mir-323b-3p ; hsa-mir-646 ; hsa-mir-6768-5p ; hsa-mir-4746-3p ; hsa-mir-3648 ; hsa-mir-875-3p ; hsa-mir-4797-5p ; hsa-mir-466 ; hsa-mir-3941 ; hsa-mir-4643 ; hsa-mir-4735-3p ; hsa-mir-4789-3p ; hsa-mir-18b-5p ; hsa-mir-18a-5p ; hsa-mir-3189-5p ; hsa-mir-4758-3p ; hsa-mir-5699-5p ; hsa-mir-1915-5p ; hsa-mir-6884-3p ; hsa-mir-3922-5p ; hsa-mir-2861 ; hsa-mir-34a-3p ; hsa-mir-3940-5p ; hsa-mir-34c-5p ; hsa-mir-101-3p ; hsa-mir-146a-5p ; hsa-mir-576-3p ; hsa-mir-211-5p ; hsa-let-7a-3p ; hsa-mir-892b ; hsa-mir-1243 ; hsa-mir-1273f ; hsa-mir-1276 ; hsa-mir-1293 ; hsa-mir-224-5p ; hsa-mir-3147 ; hsa-mir-3148 ; hsa-mir-3153 ; hsa-mir-3170 ; hsa-mir-3179 ; hsa-mir-3202 ; hsa-mir-323a-5p ; hsa-mir-342-5p ; hsa-mir-3919 ; hsa-mir-432-3p ; hsa-mir-4425 ; hsa-mir-4483 ; hsa-mir-4533 ; hsa-mir-4651 ; hsa-mir-4664-5p ; hsa-mir-4716-3p ; hsa-mir-4720-3p ; hsa-mir-4804-3p ; hsa-mir-5572 ; hsa-mir-5587-5p ; hsa-mir-608 ; hsa-mir-625-5p ; hsa-mir-651-3p ; hsa-mir-653-3p ; hsa-mir-668-3p ; hsa-mir-6733-5p ; hsa-mir-6737-5p ; hsa-mir-6739-5p ; hsa-mir-6747-5p ; hsa-mir-6794-5p ; hsa-mir-6812-5p ; hsa-mir-6819-5p ; hsa-mir-6855-5p ; hsa-mir-6885-3p ; hsa-mir-8068 ; hsa-mir-8080 ; hsa-mir-876-3p ; hsa-mir-3135a ; hsa-mir-4666a-3p ; hsa-mir-4803

Nearest miRNA

hsa-mir-10392/Upstream/568452; hsa-let-7a-2/Downstream/631197;

Nearest TSS

Nearest CpG islands

None/Target, chr11-CpG: 30/Upstream/5100, chr11-CpG: 25/Downstream/1284

Nearest cancer related gene

CCND1(OG, No orient, 0)

Upstream sequence

agatatactcgccttaaaatgatctctggggaaaatgttcaatatttcactattaagtatgatgaatagttttgtttatagatgttccttaccagattga

Downstream sequence

CCTTGATTTAAacacacagatacacacacacacacacacacacacaAACCTTCTGCCTTTGATGTTACAGATTTAATACAGTTTATTTTTAAAGATAGAT

Target sequence

AACATTTTAAAAACATAGAAAAATTCAGCAAACCATTTTTAAAGTAGAAGAGGGTTTTAGGTAGAAAAACATATTCTTGTGCTTTTCCTGATAAAGCACAGCTGTAGTGGGGTTCTAGGCATCTCTGTACTTTGCTTGCTCATATGCATGTAGTCACTTTATAAGTCATTGTATGTTATTATATTCCGTAGGTAGATGTGTAACCTCTTCACCTTATTCATGGCTGAAGTCACCTCTTGGTTACAGTAGCGTAGC