VISDB Viral Integration Site DataBase

VIS ID

TVIS20000001

Fusion event

HPV-chr1:p36.22 integration

Validated

Yes

Detection method

PCR Ion Torrent Sequencing

Data source

Curated

Sample type

Disease

Cervical intraepithelial neoplasia (CIN)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HPV

Subtype

HPV16

Reference genome

Chromosome

chr1

Cytoband

p36.22

Reference genome

Start

End

9819841/9837196 (Hg38)

Location type

Intronic

Fragile sites / regions

Target gene

CLSTN1 ; CTNNBIP1

miRNAs that regulate target gene

hsa-mir-29b-3p ; hsa-mir-215-5p ; hsa-mir-193b-3p ; hsa-mir-335-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-192-5p ; hsa-mir-26b-5p ; hsa-mir-744-5p ; hsa-mir-455-3p ; hsa-mir-423-5p ; hsa-mir-30e-3p ; hsa-mir-30a-3p ; hsa-mir-218-5p ; hsa-mir-6763-5p ; hsa-mir-6825-5p ; hsa-mir-3150a-3p ; hsa-mir-939-5p ; hsa-mir-1343-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-6797-5p ; hsa-mir-1249-5p ; hsa-mir-7154-3p ; hsa-mir-6077 ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-4751 ; hsa-mir-7155-5p ; hsa-mir-637 ; hsa-mir-8089 ; hsa-mir-4700-5p ; hsa-mir-4667-5p ; hsa-mir-4756-5p ; hsa-mir-1321 ; hsa-mir-4739 ; hsa-mir-941 ; hsa-mir-3175 ; hsa-mir-3180-5p ; hsa-mir-501-5p ; hsa-mir-5195-3p ; hsa-mir-145-5p ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-7977 ; hsa-mir-6799-5p ; hsa-mir-24-3p ; hsa-mir-3934-3p ; hsa-mir-2467-5p ; hsa-mir-3937 ; hsa-mir-383-3p ; hsa-mir-671-5p ; hsa-mir-2115-5p ; hsa-mir-4786-3p ; hsa-mir-5739 ; hsa-mir-5091 ; hsa-mir-6837-5p ; hsa-mir-4685-5p ; hsa-mir-7113-5p ; hsa-mir-488-5p ; hsa-mir-4422 ; hsa-mir-6835-3p ; hsa-mir-29c-3p ; hsa-mir-29a-3p

Nearest miRNA

hsa-mir-12136/Upstream/685419; hsa-mir-101-1/Downstream/130185;

Nearest TSS

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/12587, chr1-CpG: 113/Downstream/72591

Nearest cancer related gene

CTNNBIP1(TSG, No orient, 0)

Upstream sequence

TCTCTTCCGGCAGGTCGTAAGCCACATGCTTTCGGCCAGGGAGTTCGAGCTGGTGAGAGGGAGGGGGATACCCGTGAGGAGAATGTCCAATGTTAtatgg

Downstream sequence

gttcaattatgttcccccccaaaacttagatgttgaagtcttaacccccactaccacagaatgtgaccttatttcaaaacagggtctttacagaggttat