Basic Information
VIS ID
TVIS20000004
Fusion event
HPV-chr10:q24.2 integration
Validated
Yes
Detection method
PCR Ion Torrent Sequencing
Data source
Curated
Sample type
Tumor
Disease
Cervical intraepithelial neoplasia (CIN)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26660085
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.4
Host Sequence
Chromosome
chr10
Cytoband
q24.2
Reference genome
NCBI36/hg18
Start
99428623/97678876 (Hg38)
End
99428623/97678876 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
AVPI1 ; PI4K2A
miRNAs that regulate target gene
hsa-mir-148b-3p ; hsa-mir-128-3p ; hsa-mir-877-5p ; hsa-mir-3163 ; hsa-mir-95-5p ; hsa-mir-5692a ; hsa-mir-3124-3p ; hsa-mir-6844 ; hsa-mir-4540 ; hsa-mir-6832-3p ; hsa-mir-483-3p ; hsa-mir-6838-3p ; hsa-mir-204-5p ; hsa-mir-211-5p ; hsa-mir-9-5p
Nearest miRNA
hsa-mir-107/Upstream/850112; hsa-mir-1287/Downstream/196937;
Nearest TSS
ENST00000439456/Upstream/38190; ENST00000451097/Downstream/8447;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/37651, chr10-CpG: 76/Downstream/8063
Upstream sequence
tcctggcctcaagtgatcctcctacctcagcccctggagtagctgggaccgcaggtgcatgccaccatgcctggctaatttctcttttttttggcggggg
Downstream sequence
gagggtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgt
Reference
Bodelon, C., et al. Chromosomal copy number alterations and HPV integration in cervical precancer and invasive cancer. Carcinogenesis.2016, 37(2): 188-196.
Curate