Basic Information
VIS ID
TVIS20000005
Fusion event
HPV-ETFA integration
Validated
Yes
Detection method
APOT and sequencing
Data source
Curated
Sample type
Tumor
Disease
Cervical intraepithelial neoplasia (CIN)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26660085
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.4
Host Sequence
Chromosome
chr15
Cytoband
q24.2
Reference genome
NCBI36/hg18
Start
74295689/76216293 (Hg38)
End
74295689/76216293 (Hg38)
Location type
Intronic
Target gene
ETFA
miRNAs that regulate target gene
hsa-mir-92a-3p ; hsa-mir-25-3p ; hsa-mir-18a-5p ; hsa-let-7b-5p
Nearest miRNA
hsa-mir-10393/Upstream/453978; hsa-mir-11181/Downstream/2993495;
Nearest TSS
ENST00000557528/Upstream/24824; ENST00000558437/Downstream/10042;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/24054, chr15-CpG: 51/Downstream/94929
Upstream sequence
ATAGAGCTCTCCATGAACAAGAAAGGCaaaaaaataaataaataaacaaaatttttaCTCCTTTTCTTCAATTTTCTCTAGAGGCTAGGCATATTTCTGA
Downstream sequence
TAGTTTTAAAGCTGTGGAAAAGCTTTATTATAGATTTTAGTACAGAATTTAAAAAGTTCAAACAATAATTGTTTGGAACCACAAATAATTAAAAGGAAAC
Reference
Bodelon, C., et al. Chromosomal copy number alterations and HPV integration in cervical precancer and invasive cancer. Carcinogenesis.2016, 37(2): 188-196.
Curate