Basic Information
VIS ID
TVIS20000007
Fusion event
HPV-chr3:q28 integration
Validated
Yes
Detection method
PCR Ion Torrent Sequencing
Data source
Curated
Sample type
Tumor
Disease
Cervical intraepithelial neoplasia (CIN)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26660085
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.4
Host Sequence
Chromosome
chr3
Cytoband
q28
Reference genome
NCBI36/hg18
Start
191025132/189824649 (Hg38)
End
191025132/189824649 (Hg38)
Location type
Intronic
Target gene
MIR944 ; TP63
miRNAs that regulate target gene
hsa-mir-203a-3p ; hsa-mir-92a-3p ; hsa-mir-21-5p ; hsa-mir-124-3p ; hsa-mir-301b-3p ; hsa-mir-129-5p ; hsa-mir-6885-3p ; hsa-mir-4477b ; hsa-mir-1178-3p ; hsa-mir-6891-5p ; hsa-mir-3173-3p ; hsa-mir-4428
Nearest miRNA
hsa-let-7g/Upstream/1135783; hsa-mir-3137/Downstream/5273;
Nearest TSS
ENST00000440867/Upstream/34848; ENST00000412203/Downstream/139472;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/876886, chr3-CpG: 99/Downstream/295642
Nearest cancer related gene
MIR944(OG, No orient, 0)
Upstream sequence
GCTGTGCCGGGGCTGCTGTGAAACTGTTTTCCTGTGAAGACAGTGATTTTCTCCTTAGGGTGGCTGCTGTCACACGGCACTGCCCCTTTCCTTATAATAC
Downstream sequence
TTGATCACAGACACAGTAACATCTGTGCCTAGATCACAAGCCATACTTACTCAGGACGATTTTCCTCTTAAAGCACCAGGGAGGGAGAGGCCCTTGTCAG
Reference
Bodelon, C., et al. Chromosomal copy number alterations and HPV integration in cervical precancer and invasive cancer. Carcinogenesis.2016, 37(2): 188-196.
Curate