Basic Information
VIS ID
TVIS20000010
Fusion event
HPV-chr22:q11.23 integration
Validated
Yes
Detection method
APOT and sequencing
Data source
Curated
Sample type
Tumor
Disease
Cervical intraepithelial neoplasia (CIN)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26660085
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.4
Host Sequence
Chromosome
chr22
Cytoband
q11.23
Reference genome
NCBI36/hg18
Start
22060494/23388307 (Hg38)
End
22060494/23388307 (Hg38)
Location type
Intronic
Target gene
CES5AP1 ; ZDHHC8P1
Nearest miRNA
hsa-mir-1286/Upstream/501928; hsa-let-7a-3/Downstream/2067339;
Nearest TSS
ENST00000624155/Upstream/61691; ENST00000428415/Downstream/45257;
Nearest CpG islands
chr22-CpG: 22/Target, None/Upstream, None/Downstream
Upstream sequence
CTTCCAGCCAGTGCCCCCGCCGCAGCCGCGCCCTGTCCTGCACGACATCCCGGAGCCTGGACCTGAGGCGAACCCCCACGCCCACCCCAATCCAGGACAC
Downstream sequence
CGCTTGGCAGGGCGCTTGGCCTTTGTTAGCGTATATGACCCCGTGAGTGGGGAACCCCAGGGCTGGGGATCCAGGGCCCCGTCTCTCCAAGAGTCCCCCC
Reference
Bodelon, C., et al. Chromosomal copy number alterations and HPV integration in cervical precancer and invasive cancer. Carcinogenesis.2016, 37(2): 188-196.
Curate