Basic Information
VIS ID
TVIS20000012
Fusion event
HPV-chr7:q11.23 integration
Validated
Yes
Detection method
PCR Ion Torrent Sequencing
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26660085
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.4
Host Sequence
Chromosome
chr7
Cytoband
q11.23
Reference genome
NCBI36/hg18
Start
74757074/73075408 (Hg38)
End
74757074/73075408 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA7J
Target gene
PMS2P5 ; SPDYE8P
Nearest miRNA
hsa-mir-1183/Upstream/377430; hsa-mir-10399/Downstream/635909;
Nearest TSS
ENST00000635602/Upstream/105942; ENST00000437013/Downstream/229295;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/69013, chr7-CpG: 107/Downstream/79260
Upstream sequence
agagacaaggtttcaccatgttggccaggctggtctcaaactcctgacctcaagtgatccacccgcctcagtctcccaaagtgctgggattataggcatg
Downstream sequence
agctactgtgcccagACCCCAAGCTAGAGTTTTAAAGCAGGAAATGAGAGAAAGATATTGAGAGAGGAAAACCAGGTGGTAAGAAAACTCTAAAGGTggc
Reference
Bodelon, C., et al. Chromosomal copy number alterations and HPV integration in cervical precancer and invasive cancer. Carcinogenesis.2016, 37(2): 188-196.
Curate