Basic Information
VIS ID
TVIS20000017
Fusion event
HPV-chr8:q22.1 integration
Validated
Yes
Detection method
PCR Ion Torrent Sequencing
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26660085
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.4
Host Sequence
Chromosome
chr8
Cytoband
q22.1
Reference genome
NCBI36/hg18
Start
96153569/95072165 (Hg38)
End
96153569/95072165 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA8B
Target gene
MIR3150A ; MIR3150B ; NDUFAF6
miRNAs that regulate target gene
hsa-mir-3679-3p ; hsa-mir-6807-5p ; hsa-mir-6868-3p ; hsa-mir-6826-3p ; hsa-mir-2355-5p ; hsa-mir-1233-3p ; hsa-mir-1225-3p ; hsa-mir-3124-3p ; hsa-mir-3667-3p ; hsa-mir-6734-3p ; hsa-mir-6756-3p ; hsa-mir-3127-3p ; hsa-mir-129-2-3p ; hsa-mir-129-1-3p
Nearest miRNA
hsa-mir-12123/Upstream/1156046; hsa-mir-10400/Downstream/746;
Nearest TSS
ENST00000518652/Upstream/23699; ENST00000521063/Downstream/755;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/46793, chr8-CpG: 49/Downstream/876
Upstream sequence
TTTTACCTTCTCACCCCCAGAAATTAATCTTCGCATAAACCTCAGGACCAGCACAATGCCTGTCTCAATAAAATGTTAGTTTCCTTTCCTTCTGTATCTC
Downstream sequence
CTGCCTTCCCCTTCCTGGCCACCTAAGACACAGGGCCGTTATGTTGCGGTGCCCTACTTCGCAGCACCCCCAGACCTGCCCAGGGCTGCTCCCCATGCCA
Reference
Bodelon, C., et al. Chromosomal copy number alterations and HPV integration in cervical precancer and invasive cancer. Carcinogenesis.2016, 37(2): 188-196.
Curate