Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS20000018
Fusion event
HPV-AKAP13 integration
Validated
Yes
Detection method
PCR Ion Torrent Sequencing
Data source
Curated
Sample type
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
Host Sequence
Chromosome
chr15
Cytoband
q25.3
Reference genome
Start
End
83735261/85391026 (Hg38)
Location type
Intronic
Target gene
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-423-5p ; hsa-mir-193b-3p ; hsa-mir-484 ; hsa-mir-149-5p ; hsa-mir-16-5p ; hsa-mir-6749-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-8074 ; hsa-mir-6778-3p ; hsa-mir-4287 ; hsa-mir-4685-3p ; hsa-mir-1281 ; hsa-mir-3667-3p ; hsa-mir-6832-3p ; hsa-mir-183-5p
Nearest miRNA
hsa-mir-10393/Upstream/10364; hsa-mir-11181/Downstream/379470;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/9577, chr15-CpG: 20/Downstream/367692
Nearest cancer related gene
AKAP13(OG, No orient, 0)
Upstream sequence
ttaagtgaaggtatcagtaagcatttggatatacagttctggagttcagtgatggtctggactgggtgtatgaattagagaattgtagatagagaaggGA
Downstream sequence
GAGTGGGAGGTTTTAGTGGGAATTAGGGATATATAAAGCTCCATAATAGGGGCTCATGGCATAGTAGTTAATAATCATGACAGTCATAAAACAACCACCA
Reference
Bodelon, C., et al. Chromosomal copy number alterations and HPV integration in cervical precancer and invasive cancer. Carcinogenesis.2016, 37(2): 188-196.